NDT Advance Access originally published online on December 21, 2007
Nephrology Dialysis Transplantation 2008 23(6):1910-1918; doi:10.1093/ndt/gfm878
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Association between body mass index and chronic kidney disease in men and women: population-based study of Malay adults in Singapore
1 Department of Community, Occupational and Family Medicine 2 Centre for Molecular Epidemiology 3 Department of Statistics and Applied Probability 4 Department of Endocrinology, Singapore General Hospital 5 Singapore Eye Research Institute 6 Department of Medicine, Alexandra Hospital, Singapore 7 Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Correspondence and offprint requests to: Anoop Shankar, Department of Community, Occupational, and Family Medicine, National University of Singapore, Singapore 117597. Tel: +65-6874-4968; Fax: +65-6779-1489; E-mail: ashankar{at}nus.edu.sg
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Abstract |
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Background. In contrast to previous studies from western populations, studies from Japan reported a positive association between body mass index (BMI) and chronic kidney disease (CKD) among men but not women. In this context, we examined the relationship between BMI and CKD, by gender, in a study of Malay adults from Singapore.
Methods. This was a population-based cross-sectional sample of adults (n = 2783, 53% women, aged 49–80 years), free of clinical cardiovascular disease. The outcome of interest was presence of CKD [estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m2 (n = 517)]. The statistical methods used were logistic and nonparametric logistic regressions.
Results. Higher BMI levels were found to be positively associated with CKD among Malay men. Among men, compared to BMI quartile 1 (<23 kg/m2), the multivariable odds ratio (OR) [95% confidence intervals (CI)] of CKD was 3.12 (1.97–4.94) in quartile 2 (23–24.9 kg/m2), 2.49 (1.63–3.79) in quartile 3 (25–29.9 kg/m2) and 3.70 (2.13–6.42) in quartile 4 (
30 kg/m2); P-trend < 0.0001. In contrast, among women BMI levels were not associated with CKD; P-trend = 0.32. In nonparametric models, among men, the observed positive association between BMI and CKD appeared to be present across the full range of BMI values, without any threshold. In contrast, among women, results from nonparametric models were consistent with the conclusion of a lack of association between BMI and CKD.
Conclusions. Higher BMI levels were positively associated with CKD among men but not women in a population-based study from Singapore. These results are consistent with the hypothesis of a male gender-specific association between BMI and CKD among Asians.
Keywords: BMI; CKD; kidney disease; obese; overweight
Received for publication: 1. 6.07
Accepted in revised form: 19.11.07
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