Skip Navigation


NDT Advance Access originally published online on February 29, 2008
Nephrology Dialysis Transplantation 2008 23(6):1826-1830; doi:10.1093/ndt/gfn067
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
23/6/1826    most recent
gfn067v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Razzaque, M. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Razzaque, M. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Can patient-specific stem cell therapy enhance renal repair?*

Mohammed Shawkat Razzaque

Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA

Correspondence and offprint requests to: Mohammed Shawkat Razzaque, Department of Developmental Biology, Harvard School of Dental Medicine, Research and Education Building, Room # 304, 190 Longwood Avenue, Boston, MA 02115, USA. Tel: +1-617-432-5768; Fax: +1-617-432-5767; E-mail: mrazzaque@hms.harvard.edu. razzaquems@yahoo.com

Keywords: kidney; stem cell; therapy

The first 150 words of the full text of this article appear below.



   Stem cells
 
The advancement of stem cell biology has not only enhanced our understanding of organogenesis and tumourigenesis, but has also helped in designing stem cells as a therapeutic tool to accelerate tissue repair. Despite a complex array of genetic alterations needed for differentiation of pluripotent stem cells into a particular subset of cells, retroviral transduction of as little as three transcription factors, Oct3/4, Sox2 and Klf4, can transform adult cells into cells mimicking pluripotent embryonic stem cells [1]. The ability of reprogramming differentiated somatic cells towards pluripotency by the nuclear transfer method has paved the way to generate patient-specific stem cell therapy without ethical concerns. This article will briefly summarize the potentials of stem cell therapy to enhance renal repair.

Stem cells have the unique ability to differentiate and self-regenerate. A pleuripotent stem cell has the ability to differentiate in all the three germ layers, while the self-regenerating ability . . . [Full Text of this Article]



   Artificial generation of stem cells
 


   Stem cells of the kidney: systemic versus resident
 


   How may stem cell therapy impact renal medicine?
 


   Concluding remarks
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?