Skip Navigation


NDT Advance Access originally published online on January 16, 2008
Nephrology Dialysis Transplantation 2008 23(5):1756-1759; doi:10.1093/ndt/gfm866
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
23/5/1756    most recent
gfm866v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Staples, J.
Right arrow Articles by Levin, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Staples, J.
Right arrow Articles by Levin, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Progressive kidney disease in three sisters with elevated lipoprotein(a)

J. Staples1, P. Taylor1,2, A. Magil1,3, J. Frohlich3, S. M. Johnston4, M. Koschinsky4, C. Chan-Yan1,2 and A. Levin1,2

1 Department of Medicine 2 Division of Nephrology 3 Division of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada 4 Department of Biochemistry, Queen's University, Kingston, Ontario, Canada

Correspondence and offprint requests to: John Staples c/o Dr A Levin, University of British Columbia, Room 6010A 1081 Burrard, Vancouver BC V6Z 1Y8, Canada. Tel: +1-604-682-2344 ext 62232; Fax: +1-604-806-8120; E-mail: john.a.staples@gmail.com

Keywords: biopsy-proven deposition; chronic kidney disease; lipoprotein(a); progressive disease; uric acid

The first 150 words of the full text of this article appear below.



   Introduction
 
Lipoprotein(a) [Lp(a)] is an atherogenic, LDL-like particle of unknown physiologic function. Elevated serum concentrations of Lp(a) have been linked conceptually and epidemiologically to cardiovascular disease [1–3], but their relationship to the progression of renal disease remains much less clear, despite several hypothesized mechanisms by which this could occur [4–12].

We present a unique case of three sisters with profound elevations in serum Lp(a), progressive but unexplained impairment of kidney function, and renal biopsies demonstrating benign nephrosclerosis and apolipoprotein(a) [apo(a)] deposition.



   Case report
 
Sisters A and B came to our attention independently after screening laboratory examinations revealed asymptomatic elevations in their serum creatinine, while Sister C was referred for assessment in light of her siblings’ renal impairment. Clinical and laboratory data for each sister, and limited data for their parents, are presented in Table 1.


View this table:



  		Table 1 Clinical and laboratory results

 
At initial presentation, Sister A had no significant medical . . . [Full Text of this Article]

Clinical course
Further Lp(a) and biopsy investigations
Control patients


   Discussion
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?