Skip Navigation


NDT Advance Access originally published online on November 6, 2007
Nephrology Dialysis Transplantation 2008 23(4):1274-1277; doi:10.1093/ndt/gfm745
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
23/4/1274    most recent
gfm745v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Nikzamir, A.
Right arrow Articles by Rashidi, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nikzamir, A.
Right arrow Articles by Rashidi, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Correlates of ACE activity in macroalbuminuric type 2 diabetic patients treated with chronic ACE inhibition

Abdolrahim Nikzamir, Manouchehr Nakhjavani, Alireza Esteghamati and Armin Rashidi

Endocrinology and Metabolism Research Center, Vali-Asr Hospital, Medical Sciences/University of Tehran, Iran

Armin Rashidi, No. 12, Aramesh Alley, Mellat Park, Tehran, Iran. Tel: +98-21-22042595; E-mail: rasidiarmin{at}yahoo.com



  Abstract

The activity of the renin–angiotensin–aldosterone system (RAAS) plays an important role in the development and progression of diabetic nephropathy. However, the effect of angiotensin-converting enzyme (ACE) inhibition on the RAAS appears to be modulated by a number of factors including the I/D polymorphism of the ACE genotype. In this study, we attempted to find independent correlates of ACE activity in 121 macroalbuminuric type 2 diabetic Iranian patients under chronic ACE inhibition. Both univariate and multivariate analyses were used. The presence of the D allele was independently associated with significantly higher levels of ACE activity (with the II genotype as reference, P < 0.001, B = 27.3, 95% CI = 17.6–37.1), and this association was not eliminated by potentially confounding variables. In conclusion, the D allele is a significant independent correlate of ACE activity in macroalbuminuric type 2 diabetic Iranian patients under long-term ACE inhibition.

Keywords: ACE activity; diabetic nephropathy; macroalbuminuria; polymorphism; type 2 diabetes

Received for publication: 27. 5.07
Accepted in revised form: 25. 9.07


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.