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NDT Advance Access originally published online on November 6, 2007
Nephrology Dialysis Transplantation 2008 23(4):1274-1277; doi:10.1093/ndt/gfm745
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Correlates of ACE activity in macroalbuminuric type 2 diabetic patients treated with chronic ACE inhibition

Abdolrahim Nikzamir, Manouchehr Nakhjavani, Alireza Esteghamati and Armin Rashidi

Endocrinology and Metabolism Research Center, Vali-Asr Hospital, Medical Sciences/University of Tehran, Iran

Armin Rashidi, No. 12, Aramesh Alley, Mellat Park, Tehran, Iran. Tel: +98-21-22042595; E-mail: rasidiarmin{at}yahoo.com



  Abstract

The activity of the renin–angiotensin–aldosterone system (RAAS) plays an important role in the development and progression of diabetic nephropathy. However, the effect of angiotensin-converting enzyme (ACE) inhibition on the RAAS appears to be modulated by a number of factors including the I/D polymorphism of the ACE genotype. In this study, we attempted to find independent correlates of ACE activity in 121 macroalbuminuric type 2 diabetic Iranian patients under chronic ACE inhibition. Both univariate and multivariate analyses were used. The presence of the D allele was independently associated with significantly higher levels of ACE activity (with the II genotype as reference, P < 0.001, B = 27.3, 95% CI = 17.6–37.1), and this association was not eliminated by potentially confounding variables. In conclusion, the D allele is a significant independent correlate of ACE activity in macroalbuminuric type 2 diabetic Iranian patients under long-term ACE inhibition.

Keywords: ACE activity; diabetic nephropathy; macroalbuminuria; polymorphism; type 2 diabetes

Received for publication: 27. 5.07
Accepted in revised form: 25. 9.07


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Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
A. Nikzamir, A. Esteghamati, M. Feghhi, M. Nakhjavani, A. Rashidi, and Javad Zavar Reza
The insertion/deletion polymorphism of the angiotensin-converting enzyme gene is associated with progression, but not development, of albuminuria in Iranian patients with type 2 diabetes
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2009; 10(2): 109 - 114.
[Abstract] [PDF]


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