NDT Advance Access originally published online on February 18, 2008
Nephrology Dialysis Transplantation 2008 23(3):820-826; doi:10.1093/ndt/gfn044
© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Kidney diseases beyond nephrology: intensive care
Zaccaria Ricci1 and
Claudio Ronco2
1 Department of Pediatric Cardiosurgery, Staff Anesthesiologist, Bambino Gesù Hospital, Rome
2 Department of Nephrology, Dialysis and Transplantation, Head, S.Bortolo Hospital, Vicenza, Italy
Zaccaria Ricci, Piazza S. Onofrio 400100, Rome, Italy. Tel: +39-0644-56115; Fax: +39-0444-993949. E-mail: z.ricci@libero.it
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From renal failure to kidney injury
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Acute kidney injury (AKI) is a complex disorder that occurs
in a variety of settings with clinical manifestations ranging
from a minimal elevation in serum creatinine to anuric renal
failure [1]. It is often under-recognized and associated with
severe consequences. Recent epidemiological studies demonstrate
the wide variation in aetiologies and risk factors and describe
the increased mortality associated with this disease (particularly
when dialysis is required) [1–2]. AKI is currently recognized
as the preferred nomenclature for the clinical disorder formerly
called acute renal failure (ARF). This transition in terminology
served to emphasize that the spectrum of disease is much broader
than the subset of patients who experience kidney failure requiring
dialysis support [3]. This new nomenclature underscores the
fact that AKI exists along a continuum, recognizing that an
acute decline in kidney function is often secondary to an injury
that causes functional and/or structural
. . . [Full Text of this Article]
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Normotensive ischaemic ARF
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RIFLE in the general ICU
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Markers and biomarkers of AKI
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AKI outcomes in the last 10 years
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Fluid resuscitation: effects on outcome
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Continuous renal replacement therapy: effects on outcome
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