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NDT Advance Access originally published online on October 23, 2007
Nephrology Dialysis Transplantation 2008 23(1):390-392; doi:10.1093/ndt/gfm703
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation

Simin Goral1,*, Eline Luning Prak2,*, Jane Kearns2, Roy D. Bloom1, Erin Pierce2, Alden Doyle1, Robert Grossman1, Ali Naji3 and Malek Kamoun2

1Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA and 3Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Correspondence and offprint requests to: Malek Kamoun, MD, PhD, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, 7.020 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104-4283,USA. Tel: +215-662-4022; Fax: +215-349-5090; E-mail: malekkam@mail.med.upenn.edu

Keywords: allograft rejection; anti-HLA-DP antibodies; HLA-DP antigens; kidney transplantation

The first 10% of the full text of this article appears below.



   Introduction
 
Recent reports have suggested an association of anti-DP antibodies with allograft rejection and graft loss, in both primary kidney transplant recipients and in re-grafts [1–3]. However, in most cases, it is difficult to separate the effects of anti-HLA-DP antibodies from other anti-HLA class I and class II antibodies. Among non-conserved haplotypes, HLA-DP allele mismatches occur despite matching for HLA class I and class II loci, because of the lack of linkage disequilibrium between DP and other HLA loci [4]

Case 1
The patient is a 41-year-old Caucasian female with end-stage renal disease (ESRD) due to systemic lupus erythematosus. The patient had a history of one pregnancy and multiple . . . [Full Text of this Article]

Case 2


   Discussion
 


   Supplementary material
 

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