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NDT Advance Access originally published online on October 12, 2007
Nephrology Dialysis Transplantation 2008 23(1):385-386; doi:10.1093/ndt/gfm701
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org



Diffuse alveolar haemorrhage in a systemic lupus erythematosus patient successfully treated with rituximab: a case report

Cordula M. Nellessen1, Uwe Pöge2, Karl A. Brensing2, Tilman Sauerbruch1, Hans-Ulrich Klehr1 and Christian Rabe1

1Universitätsklinikum Bonn, Medizinische Klinik und Poliklinik I – Allgemeine Innere Medizin, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany and 2Praxis für Nieren- und Hochdruckkrankheiten, Rheinstr. 37, 53179 Bonn, Germany

Correspondence and offprint requests to: Cordula M. Nellessen, Department of Medicine I, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. Tel: +49-228-287-15507; Fax: +49-228-28714322; E-mail: cordula.nellessen@ukb.uni-bonn.de

Keywords: diffuse alveolar haemorrhage; rituximab; systemic lupus erythematosus

The first 10% of the full text of this article appears below.



   Introduction
 
Diffuse alveolar haemorrhage (DAH) often mimics, clinically and radiologically, severe pneumonia or ARDS [1]. The causes of DAH include a variety of non-infectious diseases, e.g. collagen vascular disease. In DAH associated with SLE, a regimen of corticosteroids combined with cyclophosphamide and plasma exchange is generally recommended [2]. We describe here a ventilated SLE patient with DAH refractory to standard therapies. To our knowledge, this represents the first successful application of rituximab in DAH.



   Case report
 
A 29-year-old North African female presented to our institution . . . [Full Text of this Article]



   Discussion
 

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