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Nephrology Dialysis Transplantation 2007 22(Supplement 3):iii7-iii12; doi:10.1093/ndt/gfm015
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

OPTA—Influence of inflammation/infection on anaemia therapy in haemodialysis patients

C. Wanner1, Donald Richardson2, D. Fouque3 and P. Stenvinkel4

1Universitätsklinik Würzburg, Medizinische Klinik und Poliklinik I, Abteilung Nephrologie, Josef-Schneider-Straße 2, 97080 Würzburg, Germany, 2Department of Renal Medicine, York District Hospital, Wiggington Road, York YO31 8HE, UK, 3Départment Néphrologie, Hopital E. Herriot, Place d'Arsonval, 69437 Lyon CEDEX 03, France and 4Department of Renal Medicine K56, Karolinska University Hospital Huddinge, Karolinska Institutet, 14186 Stockholm, Sweden

The first 150 words of the full text of this article appear below.



   Introduction
 
The optimal treatment of renal anaemia—OPTA—is an initiative aiming to improve anaemia care management and to achieve recommended target haemoglobin levels of >11 g/dl with highest efficiency (European Best Practice Guidelines—EBPG; [1]). Anaemia and epoetin therapy is influenced by a variety of factors such as dialysis dose, iron status, blood loss and nutritional status. Underlying inflammation and infection are very common in dialysis patients and one of the major treatment influencing factors in the management of anaemia [2–4].

The acute phase response, inflammation and infections interact with haematopoiesis on several levels. Erythropoiesis is influenced directly via reduced erythrocyte stem cell proliferation, suppressed erythropoiesis and endogenous erythropoetin production, accelerated destruction of erythrocytes, and blunting of the reactive increase in erythropoetin in response to reduced haemoglobin levels [5]. Indirectly, acute or chronic inflammation and infection also inhibit intestinal iron absorption and release of iron from macrophages . . . [Full Text of this Article]



   Diagnosis of inflammation and infection
 
Current status of inflammation in dialysis patients
Clinical and diagnostic procedures in a unit and on an individual level


   Potential sources of inflammation/infection
 


   Treatment of inflammation/infection
 


   Concomitant anaemia treatment
 

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