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Nephrology Dialysis Transplantation 2007 22(Supplement 2):ii45-ii87; doi:10.1093/ndt/gfm020
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EBPG Guideline on Nutrition

Denis Fouque1, Marianne Vennegoor2, Piet Ter Wee3, Christoph Wanner4, Ali Basci5, Bernard Canaud6, Patrick Haage7, Klaus Konner8, Jeroen Kooman9, Alejandro Martin-Malo10, Lucianu Pedrini11, Francesco Pizzarelli12, James Tattersall13, Jan Tordoir14 and Raymond Vanholder15

1Département de Néphrologie, JE 2411- Université Claude Bernard Lyon1, Lyon, France, 2Department of Nephrology, Nutrition and Dietetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK (retired), 3Department of Nephrology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands, 4Department of Medicine, Division of Nephrology, University Hospital, Würzburg, Germany, 5Department of Medicine, Division of Nephrology, Ege University Medical Faculty, Izmir, Turkey, 6Nephrology, Dialysis and Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France, 7Department of Diagnostic and Interventional Radiology, Helios Klinikum Wuppertal, University Hospital Witten/Herdecke, Germany, 8Medical Faculty University of Cologne, Medicine Clinic I, Hospital Merheim, Germany (retired), 9Department of Internal Medicine, Division of Nephrology, University Hospital Maastricht, The Netherlands, 10Nephrology Department, Reina Sofia University Hospital, Cordoba, Spain, 11Division of Nephrology and Dialysis, Bolognini Hospital, Seriate, Italy, 12Nephrology Unit, SM Annunziata Hospital, Florence, Italy, 13Department of Renal Medicine, St. James's University Hospital, Leeds, UK, 14Department of Surgery, University Hospital Maastricht, The Netherlands and 15Nephrology Section, Department of Internal Medicine, University Hospital, Ghent, Belgium

Correspondence and offprint requests to: Denis Fouque, MD, PhD, Department of Nephrology, Hôpital Edouard Herriot, 69437 Lyon cedex 03, France. E-mail: denis.fouque@chu-lyon.fr

Outline

Guideline 1. Prevalence of malnutrition and outcome
Guideline 2. Diagnosis and monitoring of malnutrition
2.1. Diagnosis of malnutrition
2.2. Monitoring and follow-up of nutritional status

Guideline 3. Recommendations for protein and energy intake
3.1. Recommended protein intake
3.2. Recommended energy intake

Recommendation 4. Recommendations for vitamins, minerals and trace elements administration in maintenance haemodialysis patients.
4.1. Vitamins
4.2. Minerals
4.3. Trace elements

Guideline 5. Treatment of malnutrition
5.1. Dietary intervention
5.2. Oral supplements and enteral feeding
5.3. Intradialytic parenteral nutrition
5.4. Anabolic agents
5.5. Other interventions: daily dialysis

Guideline 6. Metabolic acidosis

Appendices

The first 150 words of the full text of this article appear below.



   Guideline 1. Prevalence of malnutrition and outcome
 

  • Nutritional status should be assessed at the start of haemodialysis (Opinion).
  • Protein–energy malnutrition should be avoided in maintenance haemodialysis because of poor patient outcome (Evidence III).
  • In absence of malnutrition, nutritional status should be monitored every 6 months in patients <50 years of age (Opinion).
  • In patients >50 years of age, and patients undergoing maintenance dialysis for more than 5 years, nutritional status should be monitored every 3 months (Opinion).

 

Rationale
Malnutrition is considered to be one of the late complications of chronic renal failure. A sub-analysis of the Modification of Diet in Renal Disease (MDRD) study, however, demonstrated that progressive renal insufficiency was associated with a spontaneous decline in protein intake. Predialysis patients appeared to have a spontaneous protein intake of <0.7 g/kg/day [1], which is below the minimal recommended daily intake. Thus, malnutrition in haemodialysis patients may already originate during stage IV of chronic renal failure.

It has been . . . [Full Text of this Article]



   References
 


   Guideline 2. Diagnosis and monitoring of malnutrition
 


   Guideline 2.1. Diagnosis of malnutrition
 
Rationale
Dietary records
Appetite assessment
Rationale
Rationale
Rationale
Rationale
Rationale
Rationale and commentary


   (H) Technical investigations
 
Rationale
Suggestion for future research


   Guideline 2.2. Monitoring and follow-up of nutritional status
 
Rationale
Rationale


   Recommendation for future research
 
Rationale


   Technical investigations are not recommended for routine follow up
 
Rationale


   References
 


   Guideline 3. Recommendations for protein and energy intake
 
Rationale
Protein requirements
Protein requirements in the normal population chronic haemodialysis
Protein intake and nutritional status in epidemiological studies in maintenance dialysis
Is a protein intake greater than 1.2 g/kg/day harmful in chronic haemodialysis?
Protein intake and CKD mineral and bone disease
Protein intake and frequency of haemodialysis
Protein intake and inflammation


   Recommendation for further research
 
Rationale
Energy metabolism in chronic kidney disease
How to estimate daily energy expenditure?
How to estimate daily energy intake?
Is energy intake sufficient in MHD patients?


   References
 


   4. Recommendations for vitamins, minerals and trace elements administration in MHD patients
 


   4.1. Vitamins
 
4.1.1 Water-soluble vitamins
Thiamine (B1)
Rationale
Riboflavin (B2)
Rationale


   Pyridoxine (B6)
 
Rationale


   Ascorbic Acid (vitamin C)
 
Rationale


   Folic Acid (Folate, vitamin B9)
 
Rationale


   B12 (cobalamin)
 
Rationale


   Niacin (vitamin B3, nicotinamide, nicotinic acid, vitamin PP)
 
Rationale


   Biotin (vitamin B8)
 
Rationale


   Pantothenic acid (vitamin B5)
 
Rationale


   4.1.2 Fat-soluble vitamins
 
Vitamin A (retinol)
Rationale
Vitamin E (alpha-tocopherol)
Rationale
Vitamin K
Rationale


   4.2. Minerals
 
Phosphate (phosphorus)
Rationale
Calcium
Rationale
Sodium and fluid
Rationale
Potassium
Rationale


   4.3. Trace elements
 
Iron (Fe)
Rationale
Zinc (Zn)
Rationale
Selenium (Se)
Rationale


   References
 


   Guideline 5. Treatment of malnutrition
 
Rationale and commentary
Rationale
Clinical benefits of oral nutritional supplements
Clinical benefits of enteral tube feeding
Recommendations for further research
Rationale and commentary
Rationale
Recommendation for further research
Rationale


   References
 
Rationale


   References
 


   Appendices
 
Formulas (body weight, nPNA, dialysis dose, residual renal function)
Body weight: definitions
Height
Estimating height in elderly and physically disabled patients [2]
Alternative height measurements
Length forearm (ulna), knee height and arm demispan
Length of forearm (ulna) (Fig. 1)
Knee height (Fig. 2)
Demispan (Fig. 3)
Ideal body weight estimation (Tables 4 and 5)
Body mass index (BMI)
Classification of BMI
Calculating BMI in amputees [3]
Body surface
Body water
Normalized protein equivalent of total nitrogen appearance nPNA
Residual renal function: glomerular filtration rate (GFR)
Dialysis dose
Standard conditions for blood sampling


   LABORATORY METHODS
 
Serum Albumin
Bicarbonate
C-reactive protein


   TECHNICAL ASSESSMENT
 
Subjective global assessment (SGA)
Anthropometry
Handgrip strength


   References
 

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