NDT Advance Access originally published online on April 30, 2007
Nephrology Dialysis Transplantation 2007 22(9):2659-2668; doi:10.1093/ndt/gfm243
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Comparison between creatinine and cystatin C-based GFR equations in renal transplantation
1Department of Medicine, Division of Nephrology and 2Department of Pathology, Royal University Hospital, University of Saskatchewan, Canada
Correspondence and offprint requests to: Ahmed Shoker, Division of Nephrology, St. Paul's Hospital, 1702 – 20th St. West, Saskatoon, SK S7M 0Z9, Canada. Email: shoker{at}sask.usask.ca
 |
Abstract |
|---|
Background. Estimation of glomerular filtration rate (GFR) from serum creatinine (Scr) or cystatin C (Cys C) exhibit variable performances.
Methods. We compared the performances of 14 Scr and 9 Cys C estimated GFR equations using inulin clearance (Clin) as the reference test in 103 stable renal transplant populations. Bias, precision, receiving operation characteristics (ROC), accuracy within 30% ranges from the reference method and agreements of each test were compared.
Results. Mean Clin was 46.4 ± 20.9 ml/min/1.73 m2. Scr and Cys C levels correlated well with each other (r = 0.83, P < 0.0001) and with Clin (r = –0.57 and –0.53, P < 0.001, respectively). ROC analysis demonstrated no superiority of Cys C over Scr. Gats equation achieved the highest accuracy of 70% in patients with GFR 
60 ml/min/1.73 m2. In patients with GFR 60 ml/min/1.73 m2, the Nankivell equation demonstrated the highest accuracy of 73.91%. Cys C-based equations were not depicted to be thoroughly accurate. Bias, precision and agreement were otherwise similar in all GFR tests.
Conclusion. Scr-based equations did not appear to be inferior to Cys C-based equations as a means to estimate GFR in renal transplant patients.
Keywords: cystatin C; GFR; renal transplantation; serum creatinine
Received for publication: 23.11.06
Accepted in revised form: 29. 3.07
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in NDT:
- In this issue ...
NDT 2007 22: i.[Extract] [FREE Full Text]
This article has been cited by other articles:
|
|
 |
|
  R. Botev, J.-P. Mallie, C. Couchoud, O. Schuck, J.-P. Fauvel, J. F.M. Wetzels, N. Lee, N. G. De Santo, and M. Cirillo Estimating Glomerular Filtration Rate: Cockcroft-Gault and Modification of Diet in Renal Disease Formulas Compared to Renal Inulin Clearance Clin. J. Am. Soc. Nephrol., May 1, 2009; 4(5): 899 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zitta, H. Holzer, G. Reibnegger, and W. Estelberger Comment on 'Comparison between creatinine and cystatin C-based GFR equations in renal transplantation' Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1764 - 1764. [Full Text] [PDF]
|
|
|
|
|
|
U. Poge, T. M. Gerhardt, B. Stoffel-Wagner, and R. P. Woitas Need of standardization for creatinine and cystatin C-based GFR equations in renal transplantation Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1763 - 1763. [Full Text] [PDF]
|
|
|
|
|
|
P. Delanaye, E. Cavalier, J.-M. Krzesinski, and C. Mariat Cystatin C-based equations: don't repeat the same errors with analytical considerations Nephrol. Dial. Transplant., March 1, 2008; 23(3): 1065 - 1065. [Full Text] [PDF]
|
|
|
|
|
|
C. Mariat, N. Maillard, M. Phayphet, L. Thibaudin, S. Laporte, E. Alamartine, and F. Berthoux Estimated glomerular filtration rate as an end point in kidney transplant trial: where do we stand? Nephrol. Dial. Transplant., January 1, 2008; 23(1): 33 - 38. [Full Text] [PDF]
|
|