Skip Navigation


NDT Advance Access originally published online on March 29, 2007
Nephrology Dialysis Transplantation 2007 22(8):2263-2268; doi:10.1093/ndt/gfm029
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
22/8/2263    most recent
gfm029v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Yoshihara, F.
Right arrow Articles by Kawano, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yoshihara, F.
Right arrow Articles by Kawano, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Midregional proadrenomedullin reflects cardiac dysfunction in haemodialysis patients with cardiovascular disease

Fumiki Yoshihara1, Andrea Ernst2, Nils G. Morgenthaler3, Takeshi Horio1, Satoko Nakamura1, Hajime Nakahama1, Hiroto Nakata1, Andreas Bergmann2,3, Kenji Kangawa4 and Yuhei Kawano1

1Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan, 2SphingoTec GmbH, Tulpenweg 6, D-16556 Borgsdorf, 3Research Department, B.R.A.H.M.S AG, Neuendorfstrasse 25, D-16761 Hennigsdorf, Germany and 4Research Institute, National Cardiovascular Center, Suita, Osaka, Japan

Correspondence and offprint requests to: Fumiki Yoshihara, MD, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan. Email: fyoshi{at}ri.ncvc.go.jp



  Abstract

Background. Although adrenomedullin is an indicator of cardiac dysfunction in haemodialysis patients, the clinical significance of midregional proadrenomedullin has not been elucidated.

Objectives. We evaluated whether midregional proadrenomedullin reflects cardiac dysfunction, systemic inflammation or blood volume in haemodialysis patients.

Methods. Plasma midregional proadrenomedullin, C-reactive protein and delta body weight (indicating excessive blood volume), and two-dimensional as well as Doppler echocardiographic variables were measured just before haemodialysis in 70 patients with cardiovascular disease.

Results. The median value of midregional proadrenomedullin was 1.93 nmol/l before haemodialysis, and these levels were significantly reduced following haemodialysis. Log [midregional proadrenomedullin] was positively correlated with left ventricular end-systolic volume index, diameter of inferior vena cava, C-reactive protein and delta body weight (r = 0.328, r = 0.421, r = 0.356, r = 0.364), and negatively with blood pressure, deceleration time of an early diastolic filling wave, pulmonary venous flow velocity ratio and left ventricular ejection fraction (r = –0.330, r = –0.324, r = –0.479, r = –0.373). Multivariate regression analysis revealed that pulmonary venous flow velocity ratio, diameter of inferior vena cava and C-reactive protein were independently related factors for midregional proadrenomedullin concentration.

Conclusion. Plasma midregional proadrenomedullin levels increase in association with cardiac dysfunction, systemic inflammatory status and systemic blood volume in haemodialysis patients with concomitant cardiovascular disease.

Keywords: cardiac dysfunction; excessive blood volume; haemodialysis; midregional proadrenomedullin; systemic inflammatory status

Received for publication: 20. 9.06
Accepted in revised form: 9. 1.07


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.