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NDT Advance Access originally published online on April 4, 2007
Nephrology Dialysis Transplantation 2007 22(8):2136-2137; doi:10.1093/ndt/gfm180
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Renal AT 1 receptors and hypertension*

Luis M. Ruilope

Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain

Correspondence and offprint requests to: Prof. Luis Ruilope, Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain. Email: ruilope@ad-hocbox.com

Keywords: angiotensin II; arterial hypertension; AT1 receptor; kidney; left ventricular hypertrophy; natriuresis

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Arterial hypertension participates actively in the development and progression of cardiovascular risk (CVR). The kidney plays a double role of culprit in the development of arterial hypertension and victim, when it suffers the consequences of persistently elevated blood pressure. On the other hand, it has been clearly demonstrated that as soon as the kidney is damaged by arterial hypertension, there is a concomitant rise in global CVR that accounts for an enhanced prevalence of fatal and non-fatal cardiovascular events currently observed in patients with chronic kidney disease . . . [Full Text of this Article]


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