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Nephrology Dialysis Transplantation 2007 22(8):2116-2119; doi:10.1093/ndt/gfm263
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

HIV-associated renal diseases in Africa—a desperate need for additional study

Scott D. Cohen and Paul L. Kimmel

Division of Renal Diseases and Hypertension, George Washington University Medical Center

Keywords: creatinine clearance; epidemiology; glomerular filtration rate; HIV; HIV-associated nephropathy; HIV-associated glomerulonephritis; renal function

The first 150 words of the full text of this article appear below.

Since the emergence of Acquired Immune Deficiency Syndrome (AIDS) more than 25 years ago, renal disease has been recognized as a common and intimately associated complication of Human Immunodeficiency Virus (HIV) infection. It is now known that there are several renal syndromes and diseases associated with HIV infection. These diseases are more or less tightly linked with the viral infection, the expression of HIV genes in the kidney and the interaction of HIV proteins with renal cells. Approximately 50–60% of renal disease associated with HIV infection may be considered "classic HIV-associated nephropathy" (HIVAN) [1–6]. Many studies have suggested a dramatically heightened susceptibility to the development of renal disease in patients of African descent who become infected with HIV [7–11]. In the United States, the incidence of HIV-associated renal diseases, at least progressing to end-stage renal disease (ESRD), has stabilized or decreased [12]. This is . . . [Full Text of this Article]


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