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NDT Advance Access originally published online on February 1, 2007
Nephrology Dialysis Transplantation 2007 22(4):1100-1106; doi:10.1093/ndt/gfl759
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Association between the metabolic syndrome and chronic kidney disease in Chinese adults

Jing Chen1,2, Dongfeng Gu3,4, Chung-Shiuan Chen2, Xigui Wu3,4, L. Lee Hamm1, Paul Muntner1,2, Vecihi Batuman1, Chien-Hung Lee2, Paul K. Whelton1,2 and Jiang He1,2

1Department of Medicine, Tulane University School of Medicine, 2Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA, 3the Cardiovascular Institute and Fuwai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College and 4Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China

Correspondence and offprint requests to: Jing Chen, MD, MSc, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-45, New Orleans, LA 70112. Email: jchen{at}tulane.edu



  Abstract

Background. The metabolic syndrome is a common risk factor for cardiovascular and chronic kidney disease (CKD) in Western populations. We examined the relationship between the metabolic syndrome and risk of CKD in Chinese adults.

Methods. A cross-sectional survey was conducted in a nationally representative sample of 15 160 Chinese adults aged 35–74 years. The metabolic syndrome was defined as the presence of three or more of the following risk factors: elevated blood pressure, low high density lipoprotein (HDL)-cholesterol, high triglycerides, elevated plasma glucose and abdominal obesity. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 and elevated serum creatinine was defined as ≥1.14 mg/dl in men and ≥0.97 mg/dl in women (≥95th percentile of serum creatinine in Chinese men and women aged 35–44 years without hypertension or diabetes, respectively).

Results. The multivariate-adjusted odds ratios [95% confidence interval (CI)] of CKD and elevated serum creatinine in participants with compared to those without the metabolic syndrome were 1.64 (1.16, 2.32) and 1.36 (1.07, 1.73), respectively. Compared to participants without any components of the metabolic syndrome, the multivariate-adjusted odds ratios (95% CI) of CKD were 1.51 (1.02, 2.23), 1.50 (0.97, 2.32), 2.13 (1.30, 3.50) and 2.72 (1.50, 4.93) for those with 1, 2, 3, and 4 or 5 components, respectively. The corresponding multivariate-adjusted odds ratios (95% CI) of elevated serum creatinine were 1.11 (0.88, 1.40), 1.39 (1.07, 2.04), 1.47 (1.06, 2.04) and 2.00 (1.32, 3.03), respectively.

Conclusions. These findings suggest that the metabolic syndrome might be an important risk factor for CKD in Chinese adults.

Keywords: China; chronic kidney disease; cross-sectional studies; diabetes; metabolic syndrome; obesity

Received for publication: 17. 5.06
Accepted in revised form: 22.11.06


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