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NDT Advance Access originally published online on January 8, 2007
Nephrology Dialysis Transplantation 2007 22(3):712-714; doi:10.1093/ndt/gfl768
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia*

José M. López-Novoa

Instituto ‘Reina Sofía’ de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain

Correspondence and offprint requests to: Prof. Jose. M. López-Novoa, Departamento de Fisiología y Farmacología, Edificio Departamental, Campus Miguel de Unamuno. 37007 Salamanca, Spain. Email: jmlnovoa@usal.es

Keywords: endoglin; hereditary haemorrhagic telangiectasia; pre-eclampsia; pregnancy

The first 10% of the full text of this article appears below.

Pre-eclampsia is characterized by new-onset hypertension (>140/90 mmHg), proteinuria and oedema after 20 weeks of gestation in previously normotensive, non-proteinuric women. This disease occurs in 5% of pregnancies in the United States and Europe, and can be complicated by renal failure, pulmonary oedema and coagulopathy [1]. Although there has been marked progress toward understanding its pathogenesis, only little advances have been made in prediction and management of pre-eclampsia and it remains a leading cause of maternal and foetal morbidity and mortality worldwide [1].

This editorial is based in an article recently published by the Calcium for Pre-eclampsia Prevention Study Group on the prognostic value of circulating levels of endoglin (Eng) and other angiogenic . . . [Full Text of this Article]



   What is endoglin?
 


   The origin and effects of soluble endoglin
 


   Clinical consequences of these findings
 


   Conclusion
 

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