Skip Navigation


NDT Advance Access originally published online on September 21, 2007
Nephrology Dialysis Transplantation 2007 22(12):3664-3667; doi:10.1093/ndt/gfm299
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
22/12/3664    most recent
gfm299v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Materne, C.
Right arrow Articles by Wolf, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Materne, C.
Right arrow Articles by Wolf, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


(Section Editor: A. Meyrier)

Histiocytosis X and renal insufficiency

Christine Materne1, Stefan Porubsky2, Jens Gerth1, Hermann-Josef Gröne2 and Gunter Wolf1

1Department of Internal Medicine III, University of Jena and 2Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany

Correspondence and offprint requests to: Gunter Wolf, MD, Klinik für Innere Medizin III, University Hospital Jena, Erlanger Allee 101, D-07747 Jena, Germany. Email: gunter.wolf@med.uni-jena.de

Keywords: CD1a-positive cells; interstitial nephritis; Langerhans cell histiocytosis

The first 150 words of the full text of this article appear below.



   Introduction
 
Langerhans cell histiocytosis (LCH) is a rare disorder showing a wide spectrum of clinical manifestations ranging from single cutaneous lesions to multifocal systemic disease [1,2]. The typical infiltration consists of pathological monoclonal Langerhans cells together with lymphocytes, eosinophilic granulocytes and non-dendritic histiocytes [3]. Langerhans cells are antigen-presenting cells with features of dendritic cells, staining positive for CD1a [4]. One of their original functions is cutaneous immunosurveillance. LCH is rare and the incidence in adults is 1–2 cases per million, with a mean age of 35 ± 14 years, and is slightly more prevalent in males [5,6]. Histological diagnosis is made if light microscopic morphological characteristics of the disease are found with positive staining for CD1a antigen [4,7]. In addition, Birbeck granules in the lesional cell that are detected with electron microscopy are also suggestive . . . [Full Text of this Article]

Case


   Discussion
 


   Teaching points
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?