NDT Advance Access originally published online on September 22, 2007
Nephrology Dialysis Transplantation 2007 22(12):3606-3609; doi:10.1093/ndt/gfm231
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Higher plasma interleukin-18 levels associated with poor quality of sleep in peritoneal dialysis patients
1Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, 2Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, and 3Department of Diagnostics and Therapeutics, National Taiwan University Hospital, Taipei, Taiwan
Correspondence and offprint requests to: Tun-Jun Tsai, MD, PhD, No. 7, Chung-Shan South Road, Taipei 100, Taiwan. Email: tjtsai{at}ntuh.gov.tw
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Abstract |
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Background. Sleep disorders are prevalent in patients with end-stage renal disease. Increasing evidence suggests that cytokines are involved in the regulation of sleep and wakefulness. The purpose of this study was to examine the relationship between quality of sleep and plasma interleukin-18 levels in peritoneal dialysis patients.
Methods. Plasma interleukin-18 levels were determined by the enzyme-linked immunosorbent assay (ELISA) methodology in 57 peritoneal dialysis patients. Quality of sleep was measured using the Pittsburgh Sleep Quality Index. Demographic and routine laboratory data were recorded.
Results. In our cohort, the poor sleepers had higher plasma interleukin-18 levels (559.16 ± 261.22 pg/ml vs 397.49 ± 191.81 pg/ml, P = 0.01). The plasma interleukin-18 level was positively correlated with the Pittsburgh Sleep Quality Index score (r = 0.286, P = 0.031), that is, there was a positive association between higher plasma interleukin-18 levels and poorer quality of sleep.
Conclusion. This study demonstrates that interleukin-18 may be involved in sleep disorders in end-stage renal disease patients. Higher plasma interleukin-18 levels are associated with poorer quality of sleep in peritoneal dialysis patients. Whether a cause-and-effect relationship exists between interleukin-18 and quality of sleep deserves further study.
Keywords: cytokine; sleep; peritoneal dialysis; interleukin-18
Received for publication: 8. 1.07
Accepted in revised form: 26. 3.07
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