Skip Navigation


NDT Advance Access originally published online on June 25, 2007
Nephrology Dialysis Transplantation 2007 22(11):3285-3291; doi:10.1093/ndt/gfm368
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
22/11/3285    most recent
gfm368v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Chan, C. T.
Right arrow Articles by Floras, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chan, C. T.
Right arrow Articles by Floras, J. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Improvement in exercise duration and capacity after conversion to nocturnal home haemodialysis

Christopher T. Chan, Catherine F. Notarius, Anthony C. Merlocco and John S. Floras

Department of Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Ontario, Canada

Correspondence and offprint requests to: Dr Christopher T. Chan, 200 Elizabeth Street, 8N – 842, Toronto, Ontario, M5G 2C4, Canada. Email: christopher.chan{at}uhn.on.ca



  Abstract

Background. Patients with end-stage renal disease (ESRD) have a reduced exercise capacity as assessed by peak oxygen uptake (VO2peak). Nocturnal haemodialysis (NHD) augments uraemic clearance and vascular responsiveness to nitric oxide and lowers blood pressure (BP) and peripheral resistance.

Methods. To assess the impact of NHD on exercise duration and capacity, 13 consecutive ESRD patients [age: 41 ± 3; (mean ± SEM)] and healthy normal subjects (n = 14) matched for age and body mass index exercised to peak effort (VO2peak) as determined by open-circuit spirometry during a graded cycle ergometer test with a ramp increase in work rate (by 17 watts/min).

Results. Exercise was performed before, 2 and 3–6 months after conversion from conventional haemodialysis (CHD) (3 sessions per week; 4 h per session) to NHD (5–6 sessions per week; 6–8 h per session). Exercise duration increased progressively [from 617 ± 50 (CHD) to 634 ± 47 (NHD 2 months) to 682 ± 55 [NHD 3–6 months], P = 0.03) as did exercise capacity, expressed as percent of predicted (based on age, sex and body size) VO2peak, [from 66 ± 8 (CHD) to 72 ± 6 (NHD 2 months) to 75 ± 6% (NHD 3–6 months), P < 0.05).

Conclusion. Enhanced uraemia control by NHD improved both exercise duration and capacity. When coupled with augmented uraemia management, an increase in physical activity, perhaps due to more effective oxygen delivery or improved muscle metabolism, has the potential to improve the quality of life of patients with ESRD.

Keywords: end-stage renal failure; exercise capacity; muscle; nocturnal home haemodialysis; uraemia

The first two authors contributed equally to the article

Received for publication: 24. 3.07
Accepted in revised form: 14. 5.07


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
P. Komenda, M. Copland, L. Er, O. Djurdjev, and A. Levin
Outcomes of a provincial home haemodialysis programme--a two-year experience: establishing benchmarks for programme evaluation
Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2647 - 2652.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
G. K. Sakkas, V. Liakopoulos, C. Karatzaferi, and I. Stefanidis
Sleep quality and dialysis efficacy affect functional capacity in patients receiving haemodialysis therapy
Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2703 - 2704.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
C. T Chan
Reply
Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2704 - 2704.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.