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NDT Advance Access originally published online on July 19, 2007
Nephrology Dialysis Transplantation 2007 22(11):3122-3127; doi:10.1093/ndt/gfm480
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Potential risks of living kidney donation—a review

Massimo Gai1,3, Sara Giunti3, Giacomo Lanfranco2,3 and Giuseppe Paolo Segoloni1,3

1Renal Transplant Center and 2Laboratory of Nephrology, 3Department of Internal Medicine, University of Torino, ASO S. Giovanni Battista, Torino, Italy

Correspondence and offprint requests to: Dr M. Gai, SCU Nephrology, Dialysis and Transplantation, University of Torino, ASO S. Giovanni Battista, Corso Bramante 88, 10126 Torino, Italy. Email: massimogai@katamail.com

Keywords: hyperfiltration; hypertension; kidney transplantation; living donors; proteinuria; renal function

The first 150 words of the full text of this article appear below.



   Introduction
 
In recent decades, increasing interest has been shown in the concept of renal donation and its potential related consequences, particularly following original studies on the hyperfiltration damage due to renal ablation. Specifically, in humans, hyperfiltration damage following surgical kidney ablation has been observed only as a consequence of partial nephrectomy in subjects with single kidney and, in particular, in those in whom more than 75% of the kidney has been removed [1]. Current literature suggests that risks associated with living kidney donation may be acceptably low, with excellent outcomes in terms of morbidity and mortality for the donor. Moreover, renal deterioration is similar to siblings in the same family. Indeed, a number of studies, prospectively evaluating renal function and blood pressure control after nephrectomy in living donors over a period of 10–20 years, found no evidence of development of progressive renal damage [2–5]. Some other studies, . . . [Full Text of this Article]



   Perioperative risks
 


   Surgical risks and laparoscopy
 


   Long-term morbidity
 
Decrease in GFR
Increase in proteinuria
Increase in blood pressure values


   Long-term mortality and risk of CKD
 


   Quality of life and psychosocial outcome
 


   Conclusion
 

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