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NDT Advance Access originally published online on July 24, 2006
Nephrology Dialysis Transplantation 2006 21(9):2378-2379; doi:10.1093/ndt/gfl333
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translational Nephrology

Genetic predisposition—is lupus nephritis a question of copy numbers?*

Andreas Schwarting

Johannes-Gutenberg-Universitat Mainz, I. Medizinische Klinik und Poliklinik, Mainz, Germany

Correspondence and offprint requests to: Andreas Schwarting, Email: Aschwart@mail.uni-mainz.de

Keywords: genetics; lupus nephritis

The first 10% of the full text of this article appears below.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a broad spectrum of clinical features, better defined as an ‘autoimmune syndrome’ characterized by the presence of autoantibodies and immune complex deposition affecting various organ systems.

The aetiology is multifactorial with environmental, hormonal, ethnic and genetic factors.

There is strong evidence for a genetic component based on a high concordance rate of SLE in monozygotic twins (14–57%) and occurrence of SLE in 5–12% of the relatives of affected patients [1–3].

Multiple gene association and linkage analysis studies have been performed targeting the major histocompatibility . . . [Full Text of this Article]


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