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NDT Advance Access originally published online on June 9, 2006
Nephrology Dialysis Transplantation 2006 21(9):2375-2377; doi:10.1093/ndt/gfl286
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translational Nephrology

Supplementation of vitamin D and calcium: advantages and risks*

Bernardino Díaz-López and Jorge B. Cannata-Andía

Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación, Hospital Universitario Central de Asturias, Universidad de Oviedo, Spain

Correspondence and offprint requests to: Prof Jorge B. Cannata-Andía, Servicio de Metabolismo Óseo y Mineral, Instituto Reina Sofía de Investigación, Hospital Universitario Central de Asturias, Julián Clavería S/N, Oviedo 33006, Spain. Email: cannata@hca.es

Keywords: calcium; fractures; kidney stones; osteoporosis; post-menopausal women; vitamin D

The first 10% of the full text of this article appears below.

Calcium and the vitamin D hormonal system are both essential for the development and maintenance of skeletal health [1]. Calcium plays a vital role in neuromuscular function, many enzyme-mediated processes, blood clotting and in providing rigidity to the skeleton by virtue of its phosphate salts. Over 99% of the body's calcium is stored in the bone, where, apart from providing mechanical strength, it serves as a mineral reservoir that can be drawn upon to maintain normal plasma calcium. Its non-structural roles require the strict maintenance of ionized calcium concentration in tissue fluids, at the expense of the skeleton if necessary, and therefore it is the skeleton which is at risk if the supply of calcium falls short of the requirement . . . [Full Text of this Article]


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