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NDT Advance Access originally published online on January 6, 2006
Nephrology Dialysis Transplantation 2006 21(6):1702-1704; doi:10.1093/ndt/gfi131
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

Aseptic necrosis of both tali in a child with steroid-dependent nephrotic syndrome

Velibor Tasic1, Zoran Trajkovski2, Gjorgji Zafirovski3, Zoran Gucev4 and Richard S. Trompeter5

1 Department of Paediatric Nephrology, Children's Hospital, 2 Department of Radiology, 3 Department of Orthopaedics, 4 Department of Paediatric Endocrinology, Children's Hospital, University Clinical Center, Skopje, Macedonia, 5 Department of Nephro-Urology, Great Ormond Street Hospital for Sick Children, London, UK

Correspondence and offprint requests to: V. Tasic, Department of Pediatric Nephrology, Children's Hospital, 17 Vodnjanska, 1000 Skopje, Macedonia. Email: vtasic@freemail.com.mk

Keywords: aseptic necrosis; cyclosporine; nephrotic syndrome; steroid dependant; talus

The first 10% of the full text of this article appears below.



   Introduction
 
Avascular or aseptic necrosis of the talus is rarely seen in paediatric clinical practice. This is a rare finding in the absence of steroid use or significant trauma to the foot [1]. Aseptic necrosis is seen with increasing incidence in patients receiving long-term steroid treatment as in systemic lupus erythematosus or after kidney transplantation [2–5]. We report a patient, who developed aseptic necrosis of both tali during the course of treatment of nephrotic syndrome (NS).



   Case report
 
A 5-year-old female presented with moderate edema, nephrotic range proteinuria, hypoproteinaemia (46 g/l), hypoalbuminaemia (19 g/l) and hypercholesterolaemia (8.6 mmol/l). There was no haematuria; her blood pressure, creatinine clearance, and . . . [Full Text of this Article]



   Discussion
 

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