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Nephrology Dialysis Transplantation 2006 21(6):1482-1485; doi:10.1093/ndt/gfl223
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Review

The urinary sediment beyond light microscopical examination

G. Colucci1, J. Floege2 and F. P. Schena1

1 Department of Emergency and Organ Transplant, Renal Unit, University of Bari, Bari, Italy and 2 Division of Nephrology, RWTH University of Aachen, Aachen, Germany

Correspondence and offprint requests to: F. P. Schena, Department of Emergency and Organ Transplant, Renal Unit, University of Bari, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy. Email: fp.schena@nephro.uniba.it

Keywords: mRNA expression; urinary sediment; urine

The first 150 words of the full text of this article appear below.

In the present issue of NDT, Chan et al. [1] report that the messenger (m) RNA expression of T-bet (a central Th1 transcription factor), interleukin (IL)-10, transforming growth factor (TGF)-ß and MCP-1 in the urinary sediment of patients with active lupus nephritis decrease with successful immunosuppressive therapy. Importantly, various other cytokine mRNAs, including those of IL-2, -4, -12 and -18 did not change during the 6 month follow-up period. These observations extend to a number of prior studies by the same group [2,3] and add to a growing list of molecules (pro-inflammatory cytokines, fibrosis markers, etc.) that have been assessed in the urinary sediment of patients with various renal diseases (Table 1).


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  		Table 1. Studies investigating the cellular content of specific mRNAs in the urinary sediment

 
In the present review, we will summarize the key findings related to urinary mRNA measurements and critically . . . [Full Text of this Article]



   Primary glomerular disease and chronic kidney disease (CKD)
 


   Lupus nephritis
 


   Diabetic nephropathy
 


   Renal allograft
 


   Chances and potential pitfalls
 

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