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NDT Advance Access originally published online on January 5, 2006
Nephrology Dialysis Transplantation 2006 21(5):1417-1419; doi:10.1093/ndt/gfk046
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

Status epilepticus and hyperprolinaemia following recurrent gelatine administrations in a patient on peritoneal dialysis

Sabine Illsinger, Thomas Lücke, Gisela Offner, Hans Hartmann and Anibh Martin Das

Department of Paediatrics, Medical School Hanover, Germany

Correspondence and offprint requests to: A. M. Das, MD, PhD, Department of Paediatrics, Medical School Hanover, Carl-Neuberg Str. 1, D-30623 Hanover, Germany. Email: Das.Anibh@mh-hannover.de

Keywords: epilepsy; gelatine infusion; hyperprolinaemia; peritoneal dialysis; proline; renal insufficiency

The first 10% of the full text of this article appears below.



   Introduction
 
Gelatine is commonly used as a colloid volume expander in hypovolaemic shock. Up to 22% of its amino acids are proline and hydroxyproline. Accumulation of proline in patients on dialysis receiving gelatine infusions has not been described before.

We report a patient on peritoneal dialysis who developed epileptic seizures after recurrent gelatine administration leading to hyperprolinaemia.



   Case
 
We report a 19-year-old woman undergoing peritoneal dialysis for the treatment of end-stage renal failure due to congenital kidney dysplasia. She was also suffering from psychomotor retardation and congestive cardiomyopathy. Her serum lactate ranged between 3 and 4.5 mM, a possible clue to mitochondrial dysfunction. Previous investigations had failed to prove a . . . [Full Text of this Article]



   Discussion
 
Conclusion

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