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NDT Advance Access originally published online on December 19, 2005
Nephrology Dialysis Transplantation 2006 21(5):1413-1416; doi:10.1093/ndt/gfk020
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

EBV-associated nasal-type NK/T-cell lymphoma of the nasal cavity/paranasal sinus in a renal allograft recipient

Akishi Momose1, Hiroshi Mizuno1, Satoshi Kajihara1, Hisao Saitoh1, Tsuneyasu Mikuni1, Nagai Katsunori2 and Tomihisa Funyu1

Departments of 1 Urology and 2 Pathology, Oyokyo Kidney Research Institute, Hirosaki Hospital, Hirosaki, Japan

Correspondence and offprint requests to: Akishi Momose, MD, PhD, Director, Oyokyo Kidney Research Institute, Hirosaki Hospital, 90 Kozawa Yamazaki, Hirosaki, 036-8243 Japan. Email: momose-a@oyokyo.jp

Keywords: EBV-associated lymphoma; nasal-type NK/T-cell lymphoma; post-transplantation lymphoproliferative disorder; renal transplantation

The first 150 words of the full text of this article appear below.



   Introduction
 
Post-transplant lymphoproliferative disorder (PTLD) is a severe complication arising in allograft recipients treated with immunosuppressive drugs. The incidence of PTLD has risen markedly in recent years following the introduction of novel potent immunosuppressants [1]. The spectrum of PTLDs varies from polymorphic B-cell hyperplasia to non-Hodgkin's lymphoma, which includes monomorphic T-cell lymphomas, peripheral T-cell lymphomas, anaplastic large cell lymphomas and natural killer (NK)/T-cell lymphomas. The majority of PTLDs derive from the B-cell lineage; such lymphomas are often associated with active Epstein–Barr virus (EBV) infection. In contrast to B-cell PTLDs, T-cell or NK-cell PTLDs are associated with EBV infection in only a minority of cases.

We describe here an EBV-associated, nasal-type, extranodal NK/T-cell lymphoma that developed in the nasal cavity/paranasal sinus 4 years after live donor renal transplantation. We have retrospectively examined the association of the EBV titres, determined by serological testing, with lymphocyte cell counts, which were measured during . . . [Full Text of this Article]



   Case
 


   Discussion
 

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