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NDT Advance Access originally published online on March 30, 2006
Nephrology Dialysis Transplantation 2006 21(5):1174-1177; doi:10.1093/ndt/gfl102
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translational Nephrology

Ramping up endogenous defences against chronic kidney disease

Allison A. Eddy

Children's Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Washington, USA

Correspondence and offprint requests to: Dr Allison A. Eddy, The Children's Hospital and Regional Medical Center, Division of Nephrology, Mail Stop M1-5, 4800 Sand Point Way NE, Seattle, WA 98105, USA. Email: allison.eddy@seattlechildrens.org

Keywords: bone morphogenic protein-7; fibrosis; uterine sensitization-associated gene-1

The first 150 words of the full text of this article appear below.

Bone morphogenic proteins (BMPs) are a group of glycoproteins that belong to the transforming growth factor beta superfamily. Of the several members expressed in the kidney, BMP-7 (known also as osteogenic protein-1) is of particular interest to nephrologists due to its critical role in branching morphogenesis during renal development and its ability to preserve tubular epithelial cell phenotype in the face of adversity, at least in experimental models [1]. The BMP-7 null mice die in the neonatal period in renal failure due to hypoplastic kidneys [2,3]. Even in the post-natal period, the distal tubules and collecting ducts continue to be a major site of BMP-7 synthesis [4]. Reduced expression has been reported in several renal diseases including ischaemic nephropathy, diabetic nephropathy, cyclosporine nephrotoxicity and 5/6 nephrectomy [5–9]. Intervention studies with recombinant BMP-7 first demonstrated salutary effects in animal models of . . . [Full Text of this Article]


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