Skip Navigation


NDT Advance Access originally published online on January 19, 2006
Nephrology Dialysis Transplantation 2006 21(4):1082-1086; doi:10.1093/ndt/gfk024
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow An erratum has been published
Right arrow All Versions of this Article:
21/4/1082    most recent
gfk024v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Zaki, M.
Right arrow Articles by Römpler, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zaki, M.
Right arrow Articles by Römpler, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

Nephrogenic diabetes insipidus, thiazide treatment and renal cell carcinoma

Mohamed Zaki1, Torsten Schöneberg2, Tareq Al Ajrawi3, Abdul Nasser Al Said4, Katrin Sangkuhl2 and Holger Römpler2

1 Pediatric Department, Farwania Hospital, Safat, Kuwait, 2 Institute of Biochemistry, Department of Molecular Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany, 3 Pathology Unit, Laboratory Department, Farwania Hospital, Safat, Kuwait and 4 Surgical Department, Farwania Hospital, Safat, Kuwait

Correspondence and offprint requests to: Dr T. Schöneberg, Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany. Email: schoberg@medizin.unileipzig.de

Keywords: aquaporin-2; mutation; nephrogenic diabetes insipidus; renal cell carcinoma; thiazide diuretics

The first 150 words of the full text of this article appear below.



   Introduction
 
Congenital nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by the kidneys’ inability to respond to vasopressin (AVP). As a consequence, the kidney loses its concentrating ability and produces large volumes of hypotonic urine, which may lead to severe dehydration and electrolyte imbalance, mainly hypernatraemia and hyperchloraemia [1]. NDI can be accompanied by megacystis, pelvis dilatation, hydronephrosis, mental retardation and even, inner ear deafness [2,3].

Two candidate genes have been identified in humans as causes of three inherited NDI forms. The X chromosome-linked NDI is caused by inactivating mutations in the V2 vasopressin receptor (AVPR2) gene [4]. Males are seriously affected by X chromosome-linked NDI if they inherit the mutant gene, whereas females are usually not or only mildly (partial NDI) affected. The autosomal recessive and dominant NDI forms are extremely rare types of inherited NDI, affecting both genders, and are . . . [Full Text of this Article]



   Case
 


   Discussion
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?