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NDT Advance Access originally published online on December 2, 2005
Nephrology Dialysis Transplantation 2006 21(3):792-795; doi:10.1093/ndt/gfi299
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

Systemic lupus erythematosus, eosinophilic vasculitis and acalculous cholecystitis

Janet Hegarty1, Diana Yuan Yng Chiu1, Rachel J. Middleton1, Mansel M. Haeney2, Chas G. Newstead3, Ian N. Bruce4, Philip A. Kalra1 and Donal J. O'Donoghue1

1 Department of Renal Medicine, and 2 Department of Immunology, Hope Hospital, Salford, 3 Department of Renal Medicine, St James University Teaching Hospital, Leeds, 4 Rheumatism Research Centre, Central Manchester and Manchester Children's University Hospitals Trust, Manchester, UK

Correspondence and offprint requests to: Janet Hegarty, Department of Renal Medicine, Hope Hospital, Salford, UK. Email: janet.hegarty@srht.nhs.uk

Keywords: acalculous cholecystitis; eosinophilic vasculitis; renal failure; systemic lupus erythematosus

The first 150 words of the full text of this article appear below.



   Introduction
 
Patients with atypical features of a common disease often pose diagnostic challenges, as they may have two distinct disease entities, a rare manifestation of the common illness, or even a new syndrome. We describe a case of a 30-year-old woman with what we feel was a rare acute presentation of systemic lupus erythematosus (SLE), with hypereosinophilia, acalculous cholecystitis and biopsy proven eosinophilic vasculitis affecting the kidney, responding successfully to immunomodulatory therapy to date.



   Case
 
A 30-year-old woman presented with a 5 day history of fever, diarrhoea and vomiting. Closer questioning revealed a 6 week history of fatigue and flitting polyarthralgia involving wrists, hands and feet. There was no past medical history of note, in particular no respiratory tract illnesses and no history of allergy. She took no prescribed or over the counter medications. On examination she was unwell, pyrexial (39.9°C) and markedly intravascularly deplete, although her limbs were oedematous. There were . . . [Full Text of this Article]



   Discussion
 

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