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NDT Advance Access originally published online on November 22, 2005
Nephrology Dialysis Transplantation 2006 21(2):526-529; doi:10.1093/ndt/gfi279
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

Goodpasture's syndrome with massive pulmonary haemorrhage in the absence of circulating anti-GBM antibodies?

Matthias Alexander Hellmann1, Thomas Michael Gerhardt1, Christian Rabe1, Susanne Haas2, Tilman Sauerbruch1 and Rainer Peter Woitas1

1 Medizinische Klinik und Poliklinik I and 2 Zentrum für Pathologie, Universitätsklinikum Bonn, Germany

Correspondence and offprint requests to: Matthias Hellmann, Medizinische Klinik und Poliklinik, Universitätsklinikum Bonn, Germany. Email: matthias.hellmann@gmx.de or matthias.hellmann@imail.de

Keywords: anti-GBM antibodies; Goodpasture's syndrome; pulmonary haemorrhage

The first 10% of the full text of this article appears below.



   Introduction
 
Clinical manifestation of Goodpasture's syndrome is usually characterized by the combination of glomerulonephritis and diffuse alveolar haemorrhage accompanied by anti-glomerular basement membrane (GBM) antibodies in serum or tissue. In >90% of patients with Goodpasture's syndrome, anti-GBM antibodies can be detected in the serum [1]. Only 2% of the patients develop diffuse alveolar haemorrhage without clinically evident renal disease. Typically, young male smokers are affected by Goodpasture's syndrome [2,3]. Here, we report the case of a 27-year-old Polish man who developed massive pulmonary haemorrhage without any clinical signs of renal dysfunction. Moreover, no circulating anti-GBM antibodies were detectable in his serum using common laboratory methods.



   Case
 
A 27-year-old male patient who had a history of heavy smoking (15 pack-years) was referred to a local hospital after 1 week of dyspnoea and haemoptysis. He . . . [Full Text of this Article]



   Discussion
 

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