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NDT Advance Access originally published online on December 2, 2005
Nephrology Dialysis Transplantation 2006 21(2):285-287; doi:10.1093/ndt/gfi315
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translational Nephrology

Beneficial effects of intensive insulin therapy in critically ill patients

Robert W. Schrier

Correspondence and offprint requests to: Robert W. Schrier, MD. Professor of Medicine, University of Colorado Health Sciences Center, Division of Renal Diseases and Hypertension, 4200 East Ninth Avenue, Denver, CO 80262. Email: Robert.schrier@uchse.edu

Keywords: mortality and morbidity; insulin; multiple organ dysfunction; critically ill; MOD

The first 10% of the full text of this article appears below.

Critically ill patients in intensive care units (ICU) for more than a few days have a mortality of approximately 20% world-wide. These critically ill patients, in the absence of a previous diagnosis of diabetes, commonly exhibit stress hyperglycemia and insulin resistance [1]. Many of these critically ill patients die of multiorgan dysfunction (MOD) and sepsis. Since stress hyperglycemia has been shown to associate with impaired polymorphonuclear neutrophil function and bactericidal activity [2], the question arose whether lowering of blood glucose in critically ill patients would decrease morbidity and mortality.

To address this question the Leuven group of Van den Berghe and associates performed a prospective, randomized control study in 1548 patients admitted to their surgical ICU who were receiving mechanical ventilation [3]. The patients were randomly assigned to receive intensive . . . [Full Text of this Article]


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