Skip Navigation


NDT Advance Access originally published online on September 12, 2006
Nephrology Dialysis Transplantation 2006 21(12):3371-3373; doi:10.1093/ndt/gfl480
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/12/3371    most recent
gfl480v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Dragun, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dragun, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Complement-ary matching: a definite maybe*

Duska Dragun

Department of Nephrology and Center for Cardiovascular Research, Charité University Medicine Berlin, Berlin, Germany

Correspondence and offprint requests to: Dr Duska Dragun, Department of Nephrology and Critical Care Medicine, Charité CVK, Augustenburger, Platz 1, 133353 Berlin, Germany. Email: duska.dragun@charite.de

Keywords: complement; C3; C3F/S allotypes; kidney transplantation

The first 10% of the full text of this article appears below.

The mammalian complement system has evolved as an important bridge between the innate and adaptive immune system, with responsibility for host defense against pyogenic bacteria, disposal of immune complexes and the products of inflammatory injury [1]. Three different pathways (Figure 1, panel A) lead to activation of the complement system [2]. First discovered was the classical, antigen-antibody binding-initiated pathway. Of no lesser importance is the mannose-binding lectin-mediated pathway. The evolutionarily oldest complement defense is the alternative pathway [1]. The central complement protein C3 represents the point of convergence for all three recognized activation pathways and plays a decisive role in a variety of physiological and pathological processes pivotal to the complement cascade. . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?