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NDT Advance Access originally published online on October 5, 2006
Nephrology Dialysis Transplantation 2006 21(12):3349-3353; doi:10.1093/ndt/gfl490
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cell therapy for renal regeneration—time for some joined-up thinking?

Richard Poulsom1, Evangelia I. Prodromidi2, Charles D. Pusey2 and H. Terence Cook2,3

1Histopathology Unit, Cancer Research UK—London Research Institute, 2Renal Section and 3Department of Histopathology, Division of Medicine, Imperial College London, Hammersmith Campus, London, UK

Correspondence and offprint requests to: Prof. Richard Poulsom, DSc, FRCPath, Histopathology Unit, Cancer Research UK – London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. Email: richard.poulsom@cancer.org.uk

Keywords: Alport syndrome; fusion; renal regeneration; stem cells; stem therapy

The first 150 words of the full text of this article appear below.

How the kidney copes with the task of regenerating its parenchymal cells in baseline conditions, or after damage, is relatively poorly understood—particularly in comparison with the gastrointestinal tract, skin, hair follicle and cornea. There are, however, recent reports that the ‘rescue’ of tubular epithelium in models of hereditary tyrosinaemia 1 [1] and of podocytes in mice that model Alport syndrome [23] utilizes cells derived from experimentally grafted bone marrow. As this procedure is relatively simple, it may be that some will consider trying it in humans, but the mechanisms responsible are complex and poorly understood, and there are precious few reproducible results in rodents. It may be that cell therapies can eventually be developed, but our thinking about these approaches needs to be joined up, especially if the rescue relies upon cells joining together imperfectly.

Understanding the basics of stem cell biology may provide the . . . [Full Text of this Article]


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