NDT Advance Access originally published online on August 5, 2006
Nephrology Dialysis Transplantation 2006 21(11):3293-3298; doi:10.1093/ndt/gfl413
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Adriamycin nephropathy in severe combined immunodeficient (SCID) mice
1Centre for Transplantation and Renal Research, the University of Sydney at Westmead Millennium Institute and 2Centre for Kidney Research, the Children's Hospital at Westmead, Sydney, Australia
Correspondence and offprint requests to: Dr Vincent W. S. Lee, Department of Renal Medicine, Westmead Hospital, NSW 2145 Australia. Email: vincent_lee@wmi.usyd.edu.au
Keywords: adriamycin; focal segmental glomerulosclerosis; glomerulonephritis; immunodeficiency; lymphocytes; macrophages; murine model; progressive renal insufficiency
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Introduction |
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Experimental focal glomerulosclerosis is a model of chronic proteinuric renal disease that has been induced in both rats and mice. In mice, the adriamycin (ADR)-induced nephropathy model is a robust experimental analogue of human focal glomerulosclerosis [1]. Renal injury in the ADR-induced nephropathy model is characterized by changes in both the tubulointerstitial and glomerular compartments. Within the interstitium, there is an increase in interstitial volume, tubular atrophy, collagen deposition and increased numbers of CD4+ T cells, CD8+ T cells and macrophages [1]. In mice with established adriamycin nephropathy, depletion of CD4+ T lymphocytes worsens glomerular and interstitial injury [2] whilst depletion of CD8+ T lymphocytes ameliorates disease [3]. Therefore, lymphocytes play a pivotal role in renal injury in adriamycin nephropathy (AN).
The tubulointerstitium also contains other inflammatory cells such as macrophages, dendritic cells and NK cells. Using lymphocyte-deplete animals enables study of
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Subjects and methods |
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Results |
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General characteristics
Morphometric and histopathological studies
Electron microscopical studies
Immunohistochemistry
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Discussion |
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