NDT Advance Access originally published online on May 3, 2005
Nephrology Dialysis Transplantation 2005 20(8):1610-1616; doi:10.1093/ndt/gfh842
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Effect of alcohol consumption on estimated glomerular filtration rate and creatinine clearance rate
1 Department of Clinical Research, Pingtung Christian Hospital, Pingtung 900, 2 Graduate Institute of Dental Sciences, 3 Graduate Institute of Oral Health Sciences and 4 Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Correspondence and offprint requests to: Dr Yau-Jiunn Lee, Department of Clinical Research, Pingtung Christian Hospital, No. 60, Da-Lien Rd, Pingtung, 90000, Taiwan. Email: t3275{at}ms25.hinet.net
Background. Moderate alcohol consumption is widely recognized as beneficial in the prevention of cardiovascular disease, yet the renal effects of alcohol intake are still controversial. The present study is designed to investigate the influence of alcohol consumption on calculated creatinine clearance rate (CCr) and glomerular filtration rate (GFR) in a Southern Taiwan Pai-Wan aboriginal community with a high prevalence of alcohol consumption.
Methods. This is a cross-sectional community-based study. The 1466 aboriginal subjects, 40–95 years of age, are a stratified random subpopulation identified during an integrative health care programme. They were sampled for drinking patterns. The main outcome measurements were serum creatinine, estimated CCr and GFR.
Results. Subjects with alcohol consumption had significantly higher levels of serum triglycerides, high-density lipoprotein cholesterol, uric acid, estimated CCr and GFR values than non-drinkers. Their blood pressure was also significantly higher. They had lower total cholesterol and low-density lipoprotein cholesterol concentrations. Increasing alcohol consumption was independently and significantly associated with a higher level of estimated CCr and GFR when analysed as both a categorical and continuous variable.
Conclusions. The present study shows that chronic alcohol consumption has a negative effect on blood pressure and lipid profile and stimulates the estimated GFR.
Keywords: alcohol; blood pressure; creatinine clearance rate; glomerular filtration rate
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