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NDT Advance Access originally published online on May 10, 2005
Nephrology Dialysis Transplantation 2005 20(7):1517-1518; doi:10.1093/ndt/gfh900
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Letter

Large-pore haemodialysis membranes: an efficient tool for rapid removal of vancomycin after accidental overdose

The first 10% of the full text of this article appears below.

Sir,

The usual dosage of vancomycin is 40–60 mg/kg per day divided into four 1 h infusions. Its elimination is mainly renal. An overdose can be responsible for severe ototoxicity and nephrotoxicity, especially if combined with other nephrotoxic drugs such as aminoglycoside antibiotics. As long as renal function remains normal, vancomycin plasma t1/2 is 4–6 h, suggesting forced diuresis alone to reduce drug serum levels rapidly [1].

Renal failure provoked by a vancomycin overdose is responsible for an increase in plasma t1/2 . . . [Full Text of this Article]

Tim Ulinski, Georges Deschênes and Albert Bensman

Department of Pediatric Nephrology Hôpital Trousseau 26, avenue du Docteur Arnold-Netter 75571 Paris Cedex 12 France Email: tim.ulinski@trs.aphp.fr


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