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NDT Advance Access originally published online on April 26, 2005
Nephrology Dialysis Transplantation 2005 20(6):1238-1240; doi:10.1093/ndt/gfh841
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Technical Note

Estimation of heparin leak into the systemic circulation after central venous catheter heparin lock

Mohsen Agharazii, Isabelle Plamondon, Marcel Lebel, Pierre Douville and Simon Desmeules

CHUQ-L'Hôtel Dieu de Québec Hospital, Division of Nephrology, Department of Medicine, Laval University, Québec, Canada

Correspondence and offprint requests to: Mohsen Agharazii, MD, FRCPC, CHUQ-L’Hôtel Dieu de Québec Hospital, 11, Côte du Palais, Québec, Québec G1R 2J6, Canada. Email: mohsen.agharazii{at}mail.chuq.qc.ca

Background. Although most catheter problems in haemodialysis are related to infection or clotting, bleeding associated with the heparin lock is of clinical importance especially during peri-operative conditions. The objective of this in vitro study is to estimate the volume of heparin that may leak into the circulation immediately after performing a catheter lock.

Methods. Different volumes (ml) of a dextrose solution were used to perform a catheter lock on haemodialysis catheters. The tip of the catheter was placed in a test tube containing water for a pre-specified period. The final concentrations of dextrose in the test tube were used to determine the volume of solution that leaked from the catheter.

Results. When the total lumen volume was filled, the catheter leak was estimated to be 0.59±0.03 and 0.71±0.04 ml after 15 and 25 s, respectively. There was a continuous leak of 1.23±0.41, 2.20±0.34 and 3.38±0.23 ml at 5, 15 and 30 min, respectively, after performing a catheter lock on a catheter with a total lumen volume of 4.5 ml. The catheter leak was significantly reduced when only 3.7 ml of solution was used to fill the total lumen volume of 4.5 ml.

Conclusion. The present study demonstrates a significant early and late leakage from the catheter that occurs after performing a catheter lock. When applied to heparin, the volume of the unwanted catheter leak may result in adverse clinical events, especially following haemodialysis sessions and during peri-operative periods. However, these results are hypothesis-generating, and clinical studies are necessary to evaluate the efficacy of underfilling.

Keywords: blood coagulation; catheter lock; dialysis catheters; haemodialysis catheter complications; heparin; heparin leak


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