NDT Advance Access originally published online on March 29, 2005
Nephrology Dialysis Transplantation 2005 20(6):1172-1179; doi:10.1093/ndt/gfh774
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A single bolus of a low molecular weight heparin to patients on haemodialysis depletes lipoprotein lipase stores and retards triglyceride clearing
1 Department of Public Health and Clinical Medicine, Nephrology and 2 Department of Medical Biosciences, Physiological Chemistry, Umeå University, Umeå, Sweden
Correspondence and offprint requests to: Prof. Thomas Olivecrona, Department of Medical Biosciences, Physiological Chemistry, Umeå University, SE-901 87 Umeå, Sweden. Email: thomas.olivecrona{at}medbio.umu.se
Background. Low molecular weight heparins (LMWH) are increasingly used during haemodialysis (HD) to prevent clotting in the extracorporeal devices. It has been suggested that LMWH release endothelial-bound lipoprotein lipase (LPL) less efficiently than unfractionated heparin (UFH) does and thereby cause less disturbance of lipid metabolism. Evidence from in vitro studies and from animal experiments indicate, however, that both types of heparin preparations have the same ability to release endothelial LPL, but LMWH are less effective in preventing uptake and degradation of LPL in the liver. Model studies in humans indicate that LMWH cause as much depletion of LPL stores and impaired lipolysis of triglyceride (TG)-rich lipoproteins as UFH does.
Methods. Two anticoagulant regimes based on present clinical practice were compared in nine HD patients. UFH was administered as a primed infusion, whereas the LMWH (dalteparin) was given only as a single bolus pre-dialysis. Blood was sampled regularly for LPL activity and TG.
Results. LPL activity in blood was significantly lower during the dialysis with dalteparin. To explore the remaining activity at the endothelium, a bolus of UFH was given after 3 h of dialysis. The bolus brought out about the same amount of LPL, regardless of whether UFH or dalteparin had been used during dialysis. The increase in TG was significantly higher during dialysis with dalteparin.
Conclusions. This study indicates that a single bolus of dalteparin pre-dialysis interferes with the LPL system as much as, or more than an infusion of UFH does.
Keywords: dalteparin; dialysis; heparin; lipoprotein lipase; low molecular weight heparins
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