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NDT Advance Access originally published online on February 22, 2005
Nephrology Dialysis Transplantation 2005 20(5):988-990; doi:10.1093/ndt/gfh726
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Case Report

Renal tubular injury associated with anagrelide use

Graham E. J. Rodwell1, Megan L. Troxell2 and Richard A. Lafayette1

1 Division of Nephrology and 2 Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA

Correspondence and offprint requests to: Graham E. J. Rodwell, Division of Nephrology, Stanford University School of Medicine, 300 Pasteur Drive, S161, MC5114, Stanford, CA 94305–5114, USA. Email: graham.rodwell@stanford.edu

Keywords: acute renal failure; acute tubular necrosis; side effects

The first 10% of the full text of this article appears below.



   Introduction
 
We describe the first case of biopsy-proven renal tubular injury associated with anagrelide.



   Case
 
A 60-year-old man with a 35 year history of Crohn's disease was diagnosed with essential thrombocytosis (ET) following a unilateral renal artery thrombosis in May 2003. His platelet count at the time of diagnosis with ET was 1.3 million cells/mm3.

He began taking 0.5 mg oral anagrelide twice daily, increasing the dose to 1 mg each morning and 0.5 mg each evening over . . . [Full Text of this Article]



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