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NDT Advance Access originally published online on March 1, 2005
Nephrology Dialysis Transplantation 2005 20(5):985-987; doi:10.1093/ndt/gfh752
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Case Report

Combination therapy with sirolimus (rapamycin) and tacrolimus (FK-506) in treatment of refractory minimal change nephropathy, a clinical case report

Preeti Patel, Suvankar Pal, Caroline Ashley, Paul Sweny and Aine Burns

Department of Renal Medicine, Royal Free Hospital, Pond St, London NW3 2QG, UK

Correspondence and offprint requests to: Dr A. Burns, Centre for Nephrology and Transplantation, Royal Free NHS Trust, Pond St, London NW3 2QG, UK. Email: aine.burns@royalfree.nhs.uk

Keywords: cyclosporin; FK-506; minimal change nephropathy; rapamycin; sirolimus; tacrolimus

The first 10% of the full text of this article appears below.



   Introduction
 
Minimal change nephropathy (MCN) is the dominant cause of idiopathic nephrotic syndrome in childhood and accounts for ~25% of cases of adult nephrotic syndrome [1]. Each new episode of nephrotic syndrome adversely affects quality of life and is associated with complications including infection, thromboembolism and urinary loss of binding transport proteins. Proteinuria usually remits with high dose corticosteroid treatment; however, a significant minority responds incompletely or relapses frequently, providing a difficult therapeutic challenge. Furthermore, the management of frequent relapses with multiple courses of corticosteroids is associated with appreciable morbidity, including muscle atrophy, skin fragility and growth retardation. We report the use of sirolimus (rapamycin) in combination with tacrolimus (FK-506) to induce and . . . [Full Text of this Article]



   Case
 


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R. Davison and S. Fenwick
The combined use of sirolimus and cyclosporin in the management of refractory minimal change nephropathy: 'a novel use of sirolimus'
NDT Plus, October 1, 2009; 2(5): 368 - 369.
[Abstract] [Full Text] [PDF]