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NDT Advance Access originally published online on March 15, 2005
Nephrology Dialysis Transplantation 2005 20(5):864-867; doi:10.1093/ndt/gfh587
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Editorial Comment

Is vitamin D indispensable for Ca2+ homeostasis: lessons from knockout mouse models?

Joost G. J. Hoenderop and René J. M. Bindels

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands

Correspondence and offprint requests to: René J. M. Bindels, 160 Physiology, Radboud University Nijmegen Medical Centre, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands. Email: R.Bindels@ncmls.ru.nl

Keywords: calcium diet; calcium reabsorption; 25-hydroxyvitamin D3-1{alpha}-hydroxylase; microarray; TRPV5

The first 150 words of the full text of this article appear below.



   Role of vitamin D in the maintenance of Ca2+ balance
 
Calcium (Ca2+) is undoubtedly one of the most tightly regulated ions in plasma of higher animals. Ca2+ is involved in the normal functioning of a wide variety of tissues and physiological processes which include bone formation, muscle contraction, blood clotting, nerve transmission and as a second messenger regulating the actions of many hormones. The homeostasis of Ca2+ is complex because the gastrointestinal tract, the bones and the kidneys all affect the Ca2+ balance. Furthermore, the vitamin D endocrine system is critical for the proper development and maintenance of this Ca2+ homeostatic system. Once vitamin D is absorbed from the diet or made in the skin by the action of sunlight, it is metabolized in the liver to 25-hydroxyvitamin D and then the kidney serves as the endocrine gland to produce the biologically active form of vitamin D. This active form of vitamin D, 1{alpha},25-dihydroxyvitamin D3 [1,25(OH)2D3], . . . [Full Text of this Article]



   Vitamin D-deficient knockout mice models
 


   Gene products involved in high dietary Ca rescue of 1{alpha}-OHase knockout mice
 


   Is vitamin D indispensable?
 

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