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Nephrology Dialysis Transplantation 2005 20(4):834-836; doi:10.1093/ndt/gfh630
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Teaching Point
(Section Editor: K Kühn)

Supported by an educational grant from {genzyme}

A generalized seizure in a renal allograft recipient

Sophie Domhan1, Christian Morath1, Peter Schnülle2, Rüdiger Waldherr1 and Martin Zeier1

1 Department of Nephrology, University Hospital Heidelberg, Heidelberg and 2 Fifth Department of Medicine, University Hospital Mannheim, Mannheim, Germany

Correspondence and offprint requests to: Sophie Domhan, MD, University Hospital Heidelberg, Department of Nephrology, Bergheimerstraße 56a, D-69115 Heidelberg, Germany. Email: sdomhan@ix.urz.uni-heidelberg.de

Keywords: immunosuppression; primary central nervous system lymphoma (PCNSL); renal allograft; toxoplasmosis

The first 10% of the full text of this article appears below.



   Background
 
Primary central nervous system lymphoma (PCNSL) is a unique high-grade brain tumour almost always of B-cell origin which may occur in both immunocompetent and immunosuppressed patients [1]. Organ transplantation is associated with an increased risk of de novo cancer [2,3]. Skin cancer and non-Hodgkin's lymphoma are the most frequent forms of neoplasia following solid organ transplantation (23% of all malignancies) [4]. The incidence of non-Hodgkin's lymphoma is highest during the first year after kidney transplantation, with a cumulative incidence of 1% at 10 years [5]. The central nervous system (CNS) accounts for 24% of all extranodal post-transplantation lymphoproliferative disorders [4]. Two risk . . . [Full Text of this Article]



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