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Nephrology Dialysis Transplantation 2005 20(3):631-634; doi:10.1093/ndt/gfh625
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Case Report

Invasive apergillosis with myocardial involvement after kidney transplantation

Luigia Elzi1, Gerd Laifer1, Jens Bremerich2, Jürg Vosbeck3 and Michael Mayr4

1 Division of Infectious Diseases, 2 Department of Radiology, 3 Institute of Pathology and 4 Division of Transplantation Immunology and Nephrology, University Hospital Basel, 4031 Basel, Switzerland

Correspondence and offprint requests to: Michael Mayr, MD, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. E-mail: mmayr@uhbs.ch

Keywords: aspergillus endocarditis; fungal granuloma; galactomannan test; invasive aspergillosis; kidney transplantation; myocardial abscesses

The first 150 words of the full text of this article appear below.



   Introduction
 
Invasive aspergillosis (IA) has emerged as a major life-threatening infectious complication in patients with prolonged neutropenia and in solid-organ transplant recipients [1]. The frequency of IA in kidney transplantation varies between 0.5% and 2.2% [2]. The high case-fatality rate of 62% overall in renal transplant recipients and up to 88% in disseminated disease emphasizes the need for more accurate diagnostic techniques and better therapeutic options [3]. Although the recent introduction of new antifungal agents, such as voriconazole and caspofungin, offers new opportunities in the treatment of IA [4,5], optimal treatment and management of these patients remains problematic and controversial.

We discuss a case of IA with predominant thyroid and myocardial involvement after kidney transplantation, focusing on adequate therapy, duration of treatment and surveillance.



   Case
 
A 49-year-old patient with diabetic nephropathy received a cadaveric renal allograft. Cytomegalovirus status was negative for the . . . [Full Text of this Article]



   Discussion
 

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