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NDT Advance Access originally published online on February 8, 2005
Nephrology Dialysis Transplantation 2005 20(3):485-490; doi:10.1093/ndt/gfh689
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Editorial Comment

Ageing as a determinant of renal and vascular disease: role of endothelial factors

Matthias Barton

Medizinische Poliklinik, Universitätsspital, CH-8091 Zürich, Switzerland

Correspondence and offprint requests to: Matthias Barton, MD, Medizinische Poliklinik, Universitätsspital, Rämistrasse 100, CH-8091 Zürich, Switzerland. E-mail: barton@usz.ch

Keywords: endothelium; growth; hypertension; hypertrophy; inflammation; reversibility

The first 150 words of the full text of this article appear below.



   Introduction
 
In developed countries, ageing is the most important risk factor for age and death after age 28. Age also determines the onset and development of the most prominent vascular and renal diseases, atherosclerosis and glomerulosclerosis. Increased vascular and renal oxidative stress, and, as a consequence, abnormal activity of endothelium-derived molecules, such as nitric oxide (NO), angiotensin II and endothelin, are now recognized as important mechanisms controlling these disease processes. In this article, I will discuss current evidence for the involvement of endothelial factors in the genesis of vascular dysfunction and cardiorenal disease seen with ageing and present therapeutic approaches to actively interfere with these disease processes.

‘Aging changes can be attributed to development, genetic defecects, the environment, disease, and the inborn aging process

The latter is the major risk factor for disease and death after age 28 in the developed countries’.

Denham Harman [1].



   Ageing and development of cardiorenal diseases
 
The majority of deaths . . . [Full Text of this Article]



   Cell injury precedes onset and determines progression of disease
 


   Importance of the L-arginine/nitric oxide pathway
 


   Age-associated changes due to endothelial factors: truly irreversible?
 


   Therapeutic approaches
 

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