Skip Navigation


NDT Advance Access originally published online on October 4, 2005
Nephrology Dialysis Transplantation 2005 20(12):2613-2619; doi:10.1093/ndt/gfi166
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/12/2613    most recent
gfi166v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Berger, S. P.
Right arrow Articles by Daha, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berger, S. P.
Right arrow Articles by Daha, M. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Review

Complement and the kidney: What the nephrologist needs to know in 2006?

Stefan P. Berger, Anja Roos and Mohamed R. Daha

Department of Nephrology, Leiden University Medical Center, The Netherlands

Correspondence and offprint requests to: Stefan Berger, Department of Nephrology, C3-P25, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

The first 150 words of the full text of this article appear below.



   Introduction
 
The renewed appreciation of the role of the complement system as a mediator and marker of renal damage has led to numerous recent investigations in the field of complement and renal disease. The aims of the present review are:

– to recapitulate the pathways of complement activation with an emphasis on the more recently described lectin pathway of complement activation
– to discuss some of the new data on the role of complement in renal disease and,
– to briefly provide information about new diagnostic techniques in the field of complement,



   Pathways of complement activation
 
The complement system is not only an important component of the innate immune system but it also plays an essential role in the initiation and control of the adaptive immune response. The three pathways of complement activation converge at the level of C3. Activation of C3 leads to the formation of the membrane attack complex (MAC) on complement-activating surfaces (Figure 1. . . [Full Text of this Article]



   Role of complement in renal disease
 
Glomerulonephritis
Lupus nephritis
IgA-nephropathy
Ischaemia/reperfusion damage
Kidney transplantation
Atypical haemolytic-uraemic syndrome
Progression of chronic renal disease
Diabetic nephropathy


   Measurement of complement pathway activity: methods and indications
 


   Inhibitors of complement activation in the treatment of renal disease
 


   Concluding remarks
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
P. Boor, A. Konieczny, L. Villa, A.-L. Schult, E. Bucher, S. Rong, U. Kunter, C. R.C. van Roeyen, T. Polakowski, H. Hawlisch, et al.
Complement C5 Mediates Experimental Tubulointerstitial Fibrosis
J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1508 - 1515.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
P. L. Zhang, S. K. Malek, T. M. Blasick, J. R. Pennington, K. K. Masker, M. Lun, and S. Potdar
C4d Positivity Is Often Associated with Acute Cellular Rejection in Renal Transplant Biopsies Following Campath-1H (Alemtuzumab) Induction
Ann. Clin. Lab. Sci., January 1, 2007; 37(2): 121 - 126.
[Abstract] [Full Text] [PDF]