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NDT Advance Access originally published online on July 12, 2005
Nephrology Dialysis Transplantation 2005 20(10):2265-2267; doi:10.1093/ndt/gfh960
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Case Report

Hyponatraemic seizures resulting from inadequate post-operative fluid intake following a single dose of desmopressin

Zoltán Molnár1, Viktor Farkas1, László Nemes2, György S. Reusz1 and Attila J. Szabó1

1 First Department of Pediatrics, Semmelweis University, Budapest and 2 National Haemophilia Center, National Medical Center, Budapest, Hungary

Correspondence and offprint requests to: Zoltán Molnár, MD, PhD, First Department of Pediatrics, Semmelweis University, Budapest, Bókay János u. 53, H-1083 Budapest, Hungary. Email: zmolnar77@hotmail.com

Keywords: desmopressin; hyponatraemia; seizure

The first 10% of the full text of this article appears below.



   Introduction
 
1-Deamino-8-D-arginine vasopressin (desmopressin, DDAVP), a selective agonist of type 2 vasopressin receptors, has been widely used to treat enuresis. The early works of Manucci et al. have established that infusion of DDAVP elicits a rapid, transient rise in the levels of both plasma factor VIII (FVIII) and von Willebrand factor (vWF) [1]. This effect provides an approach to the treatment of mild haemophiliacs, and, according to recent guidelines, DDAVP is the treatment of choice in these patients prior to minor surgical procedures.

The administration of DDAVP is often accompanied by headache, facial flushing, a drop of blood pressure and a secondary increase in heart rate. Moreover, since free water reabsorption in renal collecting ducts is enhanced, water . . . [Full Text of this Article]



   Case
 


   Discussion
 

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