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NDT Advance Access originally published online on June 28, 2005
Nephrology Dialysis Transplantation 2005 20(10):2255-2258; doi:10.1093/ndt/gfh950
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Case Report

Recurrent rhabdomyolysis and myoglobinuric acute renal failure in a patient with polymyositis

Hyung Wook Kim, Joung Ran Choi, See Jin Jang, Yoon Sik Chang, Byung Kee Bang and Cheol Whee Park

Division of Nephrology, Department of Internal Medicine, St Vincent's Hospital, The Catholic University of Korea, Korea

Correspondence and offprint requests to: Cheol Whee Park, Division of Nephrology, Department of Internal Medicine, St Vincent's Hospital, The Catholic University of Korea, 93, Chi-Dong, Paldal-Ku, Suwon, 442-723 Korea. Email: cheolwhee@hanmail.net

Keywords: acute renal failure; myoglobin; polymyositis; rhabdomyolysis

The first 10% of the full text of this article appears below.



   Introduction
 
We report on a 57-year-old woman with polymyositis who on two occasions presented with rhabdomyolysis and myoglobinuria, with resultant oliguric acute renal failures, the second episosde of which required haemodialysis.

Polymyositis is a rare and gradually progressive autoimmune inflammatory disease of skeletal muscle that is characterized by muscle weakness, usually proximal and symmetric, elevated muscle enzymes, and distinctive findings on electromyography and muscle biopsy [1]. The disease may be associated with infections or with other collagen vascular diseases, such as Sjögren's syndrome and sarcoidosis [1].

Rhabdomyolysis is a term that refers to disintegration of striated muscle, which results in the release of muscle cell constituents, in particular myoglobin, into extracelluar fluid and the circulation. The released myoglobin is filtered by glomeruli and reaches the tubules, where it may cause obstruction and renal dysfunction [2]. The main causes of rhabdomyolysis . . . [Full Text of this Article]



   Case
 


   Discussion
 

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