NDT Advance Access originally published online on July 13, 2004
Nephrology Dialysis Transplantation 2004 19(9):2387-2393; doi:10.1093/ndt/gfh303
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Nephrol Dial Transplant Vol. 19 No. 9 © ERA-EDTA 2004; all rights reserved
Preliminary Communication
Natural history of vascular calcification in dialysis and transplant patients
Departments of 1 Medicine and 2 Radiology, Indiana University School of Medicine and 3 Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA
Correspondence and offprint requests to: Sharon M. Moe, MD, Associate Professor of Medicine, Associate Dean for Research Support, Indiana University School of Medicine, 1001 W. 10th Street; OPW 526, Indianapolis, IN 46202, USA. Email: smoe{at}iupui.edu
Background. The purpose of the present study was to determine the natural history of coronary artery and aorta calcification by spiral computed tomography (CT) in patients who undergo a renal transplant and patients on haemodialysis.
Methods. Two cohorts were evaluated for the natural history of vascular calcification: (i) 23 patients who underwent a baseline CT scan at the time of renal transplant and a repeat evaluation 15–20 months later; and (ii) 33 chronic kidney disease, stage 5 haemodialysis subjects who underwent a baseline CT scan, all followed for a minimum of 15 months, and 17 of whom underwent a second CT scan.
Results. In the patients undergoing a renal transplant, there was no net change in CAC with time, suggesting stabilization of calcification. In the haemodialysis patients, the median CAC increased by 1.27±1.88 score/days, P = 0.013. There was a trend towards increasing AoC score in both groups. All patients without calcification at baseline remained calcification free at follow-up. In the 15 months following baseline, the six dialysis patients who died had a significantly greater CAC score at baseline compared with the 24 patients who remained alive. Similarly, those patients who were hospitalized had a greater baseline CAC than patients who were not hospitalized.
Conclusion. In this preliminary study, renal transplantation appears to slow down or arrest CAC, whereas CAC progresses in haemodialysis patients. In haemodialysis patients, CAC was greater in patients who died or were hospitalized compared with those who remained alive or were not hospitalized.
Keywords: coronary artery disease; dialysis; renal transplant; spiral CT; vascular calcification
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