Nephrol Dial Transplant (2004) 19: 2130-2132
Nephrol Dial Transplant Vol. 19 No. 8 © ERA-EDTA 2004; all rights reserved
Case Report
Rapid improvement of calciphylaxis after intravenous pamidronate therapy in a patient with chronic renal failure
1 Dialysis Unit and 2 Department of Internal Medicine, Hôpital Cantonal, Fribourg, Switzerland
Correspondence and offprint requests to: Dr E. Descombes, Dialysis Unit, Hôpital Cantonal, CH-1708 Fribourg, Switzerland. Email: descombese@hopcantfr.ch
Keywords: bisphosphonates; calcific uraemic arteriolopathy; calciphylaxis; pamidronate; renal failure
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
Calciphylaxis, also called calcific uraemic arteriolopathy, is a rare disease characterized by medial calcification of the small arteries and ischaemia of the subcutaneous tissue, often leading to necrosis of subcutaneous fat and skin. It affects mainly women with chronic renal insufficiency and/or obesity. According to recent studies, calciphylaxis seems to occur more frequently than previously believed, with an incidence of 1% per year [1] and a prevalence of 4% in dialysis patients [2].
The pathogenesis of calciphylaxis is poorly understood and its treatment is largely empirical and somewhat controversial. Recent studies have emphasized the crucial role of a multidisciplinary therapeutic approach focusing on the correction of the underlying abnormalities of the calcium and phosphorus plasma concentrations (using non-calcium-containing phosphate binders), local wound care with debridement of necrotic tissues and aggressive treatment of infectious complications [3]. The utility of parathyroidectomy, corticoid therapy and hyperbaric oxygen
|
Case |
|---|
|
Discussion |
|---|
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Ketteler and P. H. Biggar What dishwashers and humans have in common? Nephrol. Dial. Transplant., November 5, 2009; (2009) gfp541v1. [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Toussaint, G. J. Elder, and P. G. Kerr Bisphosphonates in Chronic Kidney Disease; Balancing Potential Benefits and Adverse Effects on Bone and Soft Tissue Clin. J. Am. Soc. Nephrol., January 1, 2009; 4(1): 221 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Raymond and L. D. Wazny Sodium thiosulfate, bisphosphonates, and cinacalcet for treatment of calciphylaxis Am. J. Health Syst. Pharm., August 1, 2008; 65(15): 1419 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Rogers, S. H. Chang, D. J. O. Teubner, and P. T. H. Coates Hyperbaric oxygen as effective adjuvant therapy in the treatmentof distal calcific uraemic arteriolopathy NDT Plus, August 1, 2008; 1(4): 244 - 249. [Full Text] [PDF]
|
|
|
|
 |
|
 S. M Dean Atypical ischemic lower extremity ulcerations: a differential diagnosis Vascular Medicine, February 1, 2008; 13(1): 47 - 54. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Bazari, M. R. Jaff, M. Mannstadt, and S. Yan Case 7-2007 -- A 59-Year-Old Woman with Diabetic Renal Disease and Nonhealing Skin Ulcers N. Engl. J. Med., March 8, 2007; 356(10): 1049 - 1057. [Full Text] [PDF]
|
|
|
|
|
|
N. Velasco, M. S. MacGregor, A. Innes, and I. G. MacKay Successful treatment of calciphylaxis with cinacalcet--an alternative to parathyroidectomy? Nephrol. Dial. Transplant., July 1, 2006; 21(7): 1999 - 2004. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ketteler, G. Schlieper, and J. Floege Calcification and Cardiovascular Health: New Insights Into an Old Phenomenon Hypertension, June 1, 2006; 47(6): 1027 - 1034. [Full Text] [PDF]
|
|
|
|
 |
|
 W. Y. Qunibi Reducing the Burden of Cardiovascular Calcification in Patients with Chronic Kidney Disease J. Am. Soc. Nephrol., November 1, 2005; 16(11_suppl_2): S95 - S102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Guerra, R. C. Shah, and E. A. Ross Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report Nephrol. Dial. Transplant., June 1, 2005; 20(6): 1260 - 1262. [Full Text] [PDF]
|
|