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Nephrol Dial Transplant (2004) 19: 2126-2129
Nephrol Dial Transplant Vol. 19 No. 8 © ERA-EDTA 2004; all rights reserved

Case Report

Severe hypernatraemia (221 mEq/l), rhabdomyolysis and acute renal failure after cerebral aneurysm surgery

Emerson Q. Lima, Filipe C. Aguiar, Daniela M. Barbosa and Emmanuel A. Burdmann

Nephrology Division, São José do Rio Preto Medical School, São José do Rio Preto, São Paulo, Brazil

Correspondence and offprint requests to: Emmanuel A. Burdmann, São José do Rio Preto Medical School, Av. Brigadeiro Faria Lima 5416, São José do Rio Preto, SP 15090-000, Brazil. Email: burdmann@famerp.br

Keywords: acute renal failure; cerebral aneurysm; hypernatraemia; hypodipsia; rhabdomyolysis

The first 150 words of the full text of this article appear below.



   Introduction
 
Hypernatraemia is a relatively frequent electrolyte abnormality in hospitalized patients, with reported incidences ranging from 0.65 to 2.23% [1]. Normally, when the serum sodium rises, thirst develops and antidiuretic hormone (ADH) is secreted. Hypernatraemia will not occur in individuals with an intact thirst mechanism and free access to water, due to a potent osmolar stimulus to drink. Hypothalamic injuries may impair the function of the thirst regulatory centre, causing hypodipsia and hypernatraemia [2,3].

Severe hypernatraemia is a serious condition with a mortality of ≥60% [1,4]. We describe a case of a patient surviving extremely severe hypernatraemia (221 mEq/l sodium), rhabdomyolysis and acute renal failure (ARF) associated with hypodipsia and partial central diabetes insipidus after surgery to repair an aneurysm of the anterior communicating artery. Such severe hypernatraemia is unusual and there are few reported cases with serum sodium >200 mEq/l . . . [Full Text of this Article]



   Case
 


   Discussion
 

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