Nephrol Dial Transplant (2004) 19: 1916-1917
Nephrol Dial Transplant Vol. 19 No. 7 © ERA-EDTA 2004; all rights reserved
Case Report
Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthraquinones
1 Department of Medicine and 2 Department of Pathology, Queen Mary Hospital, Pokfulam, Hong Kong and 3 Department of Pathology, Princess Margaret Hospital, Lai Chi Kok, Hong Kong
Correspondence and offprint requests to: Dr Fu Keung Li, Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong. Email: fkli@hku.hk
Keywords: acute renal failure; anthraquinone; hepatitis; non-steroidal anti-inflammatory drugs; slimming
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| Introduction |
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The renal toxicities of non-steroid anti-inflammatory drugs (NSAIDs) have been well reported [1] and the mechanism of injury is thought to be mediated by haemodynamic perturbation which results in functional renal ischaemia. The typical histological abnormality is acute tubular necrosis, which is usually reversible.
Anthraquinone and its derivatives are frequently found in slimming agents and have been valued for their cathartic and presumed detoxifying action. Diarrhoea, vomiting and abdominal discomfort are common side-effects, and in severe cases, may result in dehydration. Renal and liver complications resulting from the
| Case |
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| Discussion |
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