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Nephrol Dial Transplant (2004) 19: 1916-1917
Nephrol Dial Transplant Vol. 19 No. 7 © ERA-EDTA 2004; all rights reserved


Case Report

Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthraquinones

Fu Keung Li1, Chi-Kong Lai3, Wing Tat Poon3, Albert Yan Wo Chan3, Kwok Wah Chan2, Kai Chung Tse1, Tak Mao Chan1 and Kar Neng Lai1

1 Department of Medicine and 2 Department of Pathology, Queen Mary Hospital, Pokfulam, Hong Kong and 3 Department of Pathology, Princess Margaret Hospital, Lai Chi Kok, Hong Kong

Correspondence and offprint requests to: Dr Fu Keung Li, Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong. Email: fkli@hku.hk

Keywords: acute renal failure; anthraquinone; hepatitis; non-steroidal anti-inflammatory drugs; slimming

The first 10% of the full text of this article appears below.



   Introduction
 
The renal toxicities of non-steroid anti-inflammatory drugs (NSAIDs) have been well reported [1] and the mechanism of injury is thought to be mediated by haemodynamic perturbation which results in functional renal ischaemia. The typical histological abnormality is acute tubular necrosis, which is usually reversible.

Anthraquinone and its derivatives are frequently found in slimming agents and have been valued for their cathartic and presumed detoxifying action. Diarrhoea, vomiting and abdominal discomfort are common side-effects, and in severe cases, may result in dehydration. Renal and liver complications resulting from the . . . [Full Text of this Article]



   Case
 


   Discussion
 

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